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Nitrous Oxide "analgesia": Resemblance to Opiate Action

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Journal Science
Specialty Science
Date 1976 Nov 26
PMID 982058
Citations 36
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Abstract

Nitrous oxide produced a dose-related "analgesia" in mice (median effective dose, 55 percent). The analgesia was evaluated by means of a phenylquinone writhing test. Narcotic antagonists or chronic morphinization reduced nitrous oxide analgesia. Either nitrous oxide releases an endogenous analgesic or narcotic antagonists have analgesic antagonist properties heretofore unappreciated.

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