Distribution of NADPH Diaphorase-positive Neurons in the Enteric Nervous System of the Rabbit Intestine

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 1998 Nov 6

PMID 9804278

Citations 1

Authors

C Junquera

C Martinez-Ciriano

J Blasco

J Aisa

M T Peg

M J Azanza

Affiliations

Soon will be listed here.

Abstract

Nitric oxide (NO) has been proposed as an inhibitory transmitter in gastrointestinal muscle relaxation. We analyzed the distribution of nitric-oxide producing neurons in the rabbit intestine through nicotinamide-adenine-dinucleotide-phosphate-diaphorase histochemistry. By this reliable and convenient method, we visualized neuronal nitric-oxide-synthase, the enzyme responsible for nitric oxide generation, in the rabbit intestine. In the ileum and rectum, nitric-oxide-synthase-related diaphorase activity was present in the myenteric plexus ganglion cells, and in the nerve fibers in the internodal strand, secondary, and tertiary plexuses. These fibers were particularly abundant in the deep circular rather than in the outer longitudinal muscle layer. In the inner submucosal plexus, we found scarce labeled neurons. Labeled neural somata showed a range of sizes and shapes suggesting different functional roles. The present basic information is required to use the rabbit as an experimental animal in neurochemical NO enteric research.

Citing Articles

Quantitative changes of nitrergic neurons during postnatal development of chicken myenteric plexus.

Yang P, Gandahi J, Zhang Q, Zhang L, Bian X, Wu L J Zhejiang Univ Sci B. 2013; 14(10):886-95.

PMID: 24101205 PMC: 3796640. DOI: 10.1631/jzus.B1300005.

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