Up-regulation of Thioredoxin Expression in Motor Neurons After Nerve Injury

Overview

Journal Brain Res Mol Brain Res

Specialties Molecular Biology
Neurology

Date 1998 Oct 31

PMID 9795155

Citations 7

Authors

K Mansur

Y Iwahashi

S Kiryu-Seo

Q Su

K Namikawa

J Yodoi

H Kiyama

Affiliations

Soon will be listed here.

Abstract

A substantial up-regulation of thioredoxin, a dithiol/disulfide oxido-reductase, in adult rat motoneurons following hypoglossal nerve axotomy, was demonstrated by using both in situ hybridization and immunohistochemistry. Although thioredoxin is normally accumulated more in the nucleus of a motoneuron rather than in the cytoplasm, a dramatic increase of thioredoxin in the cytoplasmic region after nerve injury was observed. The up-regulation of mRNA lasted more than 9 weeks, whereas, the detectable up-regulation of protein was observed for more than 5 weeks.

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