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Hypoxia-inducible Factor 1: Master Regulator of O2 Homeostasis

Overview
Publisher Elsevier
Specialties Biology
Genetics
Date 1998 Oct 31
PMID 9794818
Citations 327
Authors
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Abstract

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates essential homeostatic responses to reduced O2 availability in mammals. Recent studies have provided insights into the O2-dependent regulation of HIF-1 expression, target genes regulated by HIF-1, and the effects of HIF-1 deficiency on cellular physiology and embryonic development.

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