Effect of Vernonia Cinerea Less Flower Extract in Adjuvant-induced Arthritis

Overview

Journal Gen Pharmacol

Specialty Pharmacology

Date 1998 Oct 29

PMID 9792223

Citations 22

Authors

R M Latha

T Geetha

P Varalakshmi

Affiliations

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Abstract

1. The anti-inflammatory effect of an alcoholic extract from the flower of Vernonia cinerea (Asteraceae; Less) was tested in adjuvant arthritic rats. 2. Changes in paw volume, body and tissue weights and serum and tissue enzyme activities of ALT, AST, ACP and cathepsin-D in adjuvant rats were reversed by oral administration of 100 mg/kg body weight (BW) of the flower extract. 3. The extract also reversed the major histopathological changes in the hindpaws of the arthritic rats. 4. Phytochemical studies revealed the presence of alkaloids, saponins, steroids and flavonoids. 5. It is concluded that the extract contains as yet unidentified anti-inflammatory principle(s).

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