Cholinergic Foundations of Alzheimer's Disease Therapy

Overview

Journal J Physiol Paris

Specialty Physiology

Date 1998 Oct 28

PMID 9789824

Citations 12

Authors

E Giacobini

Affiliations

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Abstract

Cholinesterase inhibitors (ChEI) represent the drug of choice for Alzheimer's disease (AD) treatment. They produce significant improvement on cognitive as well as non-cognitive function for a period up to 1 year during the first 3 years following clinical diagnosis. The magnitude of cognitive improvements is similar for different ChEI, however, differences are seen with regard to incidence and severity of side effects, optimal ChE inhibition, pharmacokinetic properties and mode of administration.

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