Management of Infections Due to Antibiotic-resistant Streptococcus Pneumoniae

Overview

Journal Clin Microbiol Rev

Publisher American Society for Microbiology

Specialty Microbiology

Date 1998 Oct 10

PMID 9767060

Citations 55

Authors

S L Kaplan

E O Mason Jr

Affiliations

Soon will be listed here.

Abstract

Antibiotic-resistant strains of Streptococcus pneumoniae are becoming more prevalent throughout the world; this has resulted in modifications of treatment approaches. Management of bacterial meningitis has the greatest consensus. Strategies for treating other systemic infections such as pneumonia, bacteremia, and musculoskeletal infections are evolving, in part related to the availability of new antibiotics which are active in vitro against isolates resistant to penicillin and the extended-spectrum cephalosporins. However, there are currently very limited data related to the clinical efficacy of these new agents. The studies upon which current recommendations are based are reviewed. Otitis media represents the single most common infection due to S. pneumoniae. Recommendations for treatment of acute otitis media due to drug-resistant strains and the rationale for these recommendations are discussed.

Citing Articles

Molecular Profile and the Effectiveness of Antimicrobials Drugs Against and in the Diagnostic Approaches of Otitis Infection.

Almuhayawi M, Gattan H, Alruhaili M, Alharbi M, Nagshabandi M, Tarabulsi M Infect Drug Resist. 2023; 16:4397-4408.

PMID: 37431447 PMC: 10329836. DOI: 10.2147/IDR.S418685.

Antibiotic resistance pattern, capsular types, and molecular characterization of invasive isolates of Streptococcus pneumoniae in the south of Tunisia from 2012 to 2018.

Ktari S, Ben Ayed N, Ben Rbeh I, Garbi N, Maalej S, Mnif B BMC Microbiol. 2023; 23(1):36.

PMID: 36739390 PMC: 9898894. DOI: 10.1186/s12866-023-02784-2.

activity of lactone ketolide nafithromycin (WCK 4873) against isolates enriched with macrolide-resistance phenotype collected from mainland China.

Zhou M, Wu L, Kang W, Li Y, Zhang G, Zhang J JAC Antimicrob Resist. 2022; 4(5):dlac103.

PMID: 36226226 PMC: 9549737. DOI: 10.1093/jacamr/dlac103.

Examining the Efficacy of Antimicrobial Therapy in Preventing the Development of Postinfectious Glomerulonephritis: A Systematic Review and Meta-Analysis.

Bateman E, Mansour S, Okafor E, Arrington K, Hong B, Cervantes J Infect Dis Rep. 2022; 14(2):176-183.

PMID: 35314652 PMC: 8938805. DOI: 10.3390/idr14020022.

Antifungal and Larvicidal Activities of Phlorotannins from Brown Seaweeds.

Negara B, Sohn J, Kim J, Choi J Mar Drugs. 2021; 19(4).

PMID: 33923448 PMC: 8073715. DOI: 10.3390/md19040223.

References

Catalan M, Fernandez J, Vazquez A, Varela de Seijas E, Suarez A, Bernaldo De Quiros J . Failure of cefotaxime in the treatment of meningitis due to relatively resistant Streptococcus pneumoniae. Clin Infect Dis. 1994; 18(5):766-9. DOI: 10.1093/clinids/18.5.766. View

Barnett E, Teele D, Klein J, Cabral H, Kharasch S . Comparison of ceftriaxone and trimethoprim-sulfamethoxazole for acute otitis media. Greater Boston Otitis Media Study Group. Pediatrics. 1997; 99(1):23-8. DOI: 10.1542/peds.99.1.23. View

Asensi F, Otero M, Perez-Tamarit D, Cabedo J, Gresa S, Canton E . Risk/benefit in the treatment of children with imipenem-cilastatin for meningitis caused by penicillin-resistant pneumococcus. J Chemother. 1993; 5(2):133-4. DOI: 10.1080/1120009x.1993.11739221. View

Friedland I . Comparison of the response to antimicrobial therapy of penicillin-resistant and penicillin-susceptible pneumococcal disease. Pediatr Infect Dis J. 1995; 14(10):885-90. DOI: 10.1097/00006454-199510000-00013. View

Pichichero M, Pichichero C . Persistent acute otitis media: I. Causative pathogens. Pediatr Infect Dis J. 1995; 14(3):178-83. DOI: 10.1097/00006454-199503000-00002. View

Welby P, Keller D, Cromien J, Tebas P, Storch G . Resistance to penicillin and non-beta-lactam antibiotics of Streptococcus pneumoniae at a children's hospital. Pediatr Infect Dis J. 1994; 13(4):281-7. DOI: 10.1097/00006454-199404000-00007. View

McCracken Jr G, Nelson J, Kaplan S, Overturf G, Rodriguez W, Steele R . Consensus report: antimicrobial therapy for bacterial meningitis in infants and children. Pediatr Infect Dis J. 1987; 6(6):501-5. View

Kim Y, Liu Q, Chow L, Tauber M . Trovafloxacin in treatment of rabbits with experimental meningitis caused by high-level penicillin-resistant Streptococcus pneumoniae. Antimicrob Agents Chemother. 1997; 41(5):1186-9. PMC: 163879. DOI: 10.1128/AAC.41.5.1186. View

Craig W, Andes D . Pharmacokinetics and pharmacodynamics of antibiotics in otitis media. Pediatr Infect Dis J. 1996; 15(3):255-9. DOI: 10.1097/00006454-199603000-00015. View

10.

Scaglione F, Raichi M, Fraschini F . Serum protein binding and extravascular diffusion of methoxyimino cephalosporins. Time courses of free and total concentrations of cefotaxime and ceftriaxone in serum and pleural exudate. J Antimicrob Chemother. 1990; 26 Suppl A:1-10. DOI: 10.1093/jac/26.suppl_a.1. View

11.

Hieber J, Nelson J . A pharmacologic evaluation of penicillin in children with purulent meningitis. N Engl J Med. 1977; 297(8):410-3. DOI: 10.1056/NEJM197708252970802. View

12.

Visalli M, Jacobs M, Appelbaum P . MIC and time-kill study of activities of DU-6859a, ciprofloxacin, levofloxacin, sparfloxacin, cefotaxime, imipenem, and vancomycin against nine penicillin-susceptible and -resistant pneumococci. Antimicrob Agents Chemother. 1996; 40(2):362-6. PMC: 163117. DOI: 10.1128/AAC.40.2.362. View

13.

Hoberman A, Paradise J, Block S, Burch D, Jacobs M, Balanescu M . Efficacy of amoxicillin/clavulanate for acute otitis media: relation to Streptococcus pneumoniae susceptibility. Pediatr Infect Dis J. 1996; 15(10):955-62. DOI: 10.1097/00006454-199610000-00034. View

14.

van Dyk J, Terespolsky S, Meyer C, van Niekerk C, Klugman K . Penetration of cefpodoxime into middle ear fluid in pediatric patients with acute otitis media. Pediatr Infect Dis J. 1997; 16(1):79-81. DOI: 10.1097/00006454-199701000-00020. View

15.

Guibert M, Chahime H, Petit J, Odievre M, Labrune P . Failure of cefotaxime treatment in two children with meningitis caused by highly penicillin-resistant Streptococcus pneumoniae. Acta Paediatr. 1995; 84(7):831-3. DOI: 10.1111/j.1651-2227.1995.tb13771.x. View

16.

McIntyre P, Berkey C, King S, Schaad U, Kilpi T, Kanra G . Dexamethasone as adjunctive therapy in bacterial meningitis. A meta-analysis of randomized clinical trials since 1988. JAMA. 1997; 278(11):925-31. DOI: 10.1001/jama.278.11.925. View

17.

Pacheco T, Cooper C, Hardy D, Betts R, Bonnez W . Failure of cefotaxime treatment in an adult with Streptococcus pneumoniae meningitis. Am J Med. 1997; 102(3):303-5. DOI: 10.1016/S0002-9343(99)80271-X. View

18.

Mason Jr E, Lamberth L, Kaplan S . In vitro activities of oxazolidinones U-100592 and U-100766 against penicillin-resistant and cephalosporin-resistant strains of Streptococcus pneumoniae. Antimicrob Agents Chemother. 1996; 40(4):1039-40. PMC: 163257. DOI: 10.1128/AAC.40.4.1039. View

19.

Ahronheim G, Reich B, Marks M . Penicillin-insensitive pneumococci. Case report and review. Am J Dis Child. 1979; 133(2):187-91. DOI: 10.1001/archpedi.1979.02130020079017. View

20.

Arditi M, Mason Jr E, Bradley J, Tan T, Barson W, Schutze G . Three-year multicenter surveillance of pneumococcal meningitis in children: clinical characteristics, and outcome related to penicillin susceptibility and dexamethasone use. Pediatrics. 1998; 102(5):1087-97. DOI: 10.1542/peds.102.5.1087. View