The Visuo-motor Pathway in the Local Circuit of the Rat Superior Colliculus

Overview

Journal J Neurosci

Specialty Neurology

Date 1998 Oct 8

PMID 9763492

Citations 40

Authors

T Isa

T Endo

Y Saito

Affiliations

Soon will be listed here.

Abstract

Intrinsic circuit of the superior colliculus (SC), in particular the pathway from the optic tract (OT) to neurons in the intermediate layer (SGI), was investigated by whole-cell patch-clamp recording in slice preparations obtained from 17- to 24-d-old rats. Stimulation of the OT induced monosynaptic EPSPs in neurons in the superficial gray layer (SGS) and the optic layer (SO), and disynaptic or polysynaptic EPSPs in a majority of SGI neurons. Stimulation of the SGS induced monosynaptic or oligosynaptic EPSPs in the SGI neurons. Both the monosynaptic EPSPs induced in the SGS/SO neurons by stimulation of the OT and those induced in the SGI neurons by stimulation of the SGS were mediated by AMPA- and NMDA-type glutamate receptors. Thus, we have clarified the existence of the glutamatergic excitatory pathway from the OT to the SGI neurons via SGS and SO neurons. The EPSPs in the SGI neurons induced by stimulation of the OT or SGS were remarkably enhanced by bicuculline, suggesting that the signal transmission in this pathway is under strong suppression by the GABAergic system.

Citing Articles

Kinetic features dictate sensorimotor alignment in the superior colliculus.

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Pathways from the Superior Colliculus to the Basal Ganglia.

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The Superior Colliculus: Cell Types, Connectivity, and Behavior.

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The tectum/superior colliculus as the vertebrate solution for spatial sensory integration and action.

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