Non-evidence of Estrogen Receptors in the Rectal Mucosa

Overview

Journal Int Urogynecol J Pelvic Floor Dysfunct

Specialties Gynecology & Obstetrics
Urology

Date 1998 Sep 24

PMID 9745971

Citations 2

Authors

D E Rizk

T E Helal

N Mason

B Berg

Affiliations

Soon will be listed here.

Abstract

The aim of the study was to investigate whether estrogen receptors are present in the rectal mucosa of premenopausal women compared to postmenopausal women and men. Thirty biopsies obtained from the rectal mucosa at colonoscopy, performed to investigate inflammatory bowel disease in 23 patients and neoplasia in 7, were examined by the avidin-biotin-peroxidase immunohistochemical technique for the presence of estrogen receptors. The study group (n = 10) were non-pregnant premenopausal women and the control group (n = 20) were postmenopausal women (n = 10) and men (n = 10). None of the subjects had fecal incontinence or was taking medication with hormones. In no case did the primary lesion involve the specimen used for laboratory analysis. All samples showed negative immunostaining for estrogen receptors. It was concluded that in continent women and men, a direct estrogenic effect on the rectal mucosa seems unlikely.

Citing Articles

Effect of oestrogen therapy on faecal incontinence in postmenopausal women: a systematic review.

Bach F, Sairally B, Latthe P Int Urogynecol J. 2020; 31(7):1289-1297.

PMID: 32130466 PMC: 7306041. DOI: 10.1007/s00192-020-04252-1.

Factors impacting quality of life in women with fecal incontinence.

Markland A, Greer W, Vogt A, Redden D, Goode P, Burgio K Dis Colon Rectum. 2010; 53(8):1148-54.

PMID: 20628278 PMC: 2906823. DOI: 10.1007/DCR.0b013e3181d5da6c.

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