The Effect of Pindolol on Plasma Renin Activity and Blood Pressure in Hypertensive Patients

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 1976 Jun 1

PMID 973972

Citations 3

Authors

R Lancaster

T J Goodwin

W S Peart

Affiliations

Soon will be listed here.

Abstract

1 The effect of pindolol administered to twenty-six patients with hypertension of unknown origin was compared with respect to blood pressure and plasma renin activity change after increase of the dose over a period of 6 weeks. 2 There was no clear correlation between the fall of plasma renin activity, which in some patients was very marked, and the fall in blood pressure. Some patients with a fall in plasma renin activity did not drop their pressure. Conversely, some with a fall of pressure did not drop their plasma renin activity. 3 The addition of hydrochlorothiazide to the pindolol finally caused further lowering of the blood pressure in all but one patient and the plasma renin activity rose in all but two patinets. There was no clear correlation between change in plasma renin activity and the effect on blood pressure.

Citing Articles

A standard approach to compiling clinical pharmacokinetic data.

Sheiner L, Benet L, Pagliaro L J Pharmacokinet Biopharm. 1981; 9(1):59-127.

PMID: 7014827 DOI: 10.1007/BF01059343.

Bioavailability and disposition of metoprolol and hydrochlorothiazide combined in one tablet and of separate doses of hydrochlorothiazide.

Jordo L, Johnsson G, Lundborg P, Persson B, Regardh C, Ronn O Br J Clin Pharmacol. 1979; 7(6):563-7.

PMID: 465277 PMC: 1429665. DOI: 10.1111/j.1365-2125.1979.tb04643.x.

The second Lilly Prize Lecture, University of Newcastle, July 1977. beta-Adrenergic receptor blockade in hypertension, past, present and future.

Prichard B Br J Clin Pharmacol. 1978; 5(5):379-99.

PMID: 26370 PMC: 1429347. DOI: 10.1111/j.1365-2125.1978.tb01644.x.

References

Bravo E, TARAZI R, DUSTAN H . Beta-adrenergic blockade in diuretic-treated patients with essential hypertension. N Engl J Med. 1975; 292(2):66-70. DOI: 10.1056/NEJM197501092920203. View

Dollery C, LEWIS P, Myers M, Reid J . Central hypotensive effect of propranolol in the rabbit. Br J Pharmacol. 1973; 48(2):343P. PMC: 1776222. View

Weber M, Thornell I, Stokes G . Effects of beta adrenergic blocking agents on plasma renin activity in the conscious rabbit. J Pharmacol Exp Ther. 1974; 188(1):234-40. View

Stokes G, Weber M, Thornell I . Beta-blockers and plasma renin activity in hypertension. Br Med J. 1974; 1(5897):60-2. PMC: 1632883. DOI: 10.1136/bmj.1.5897.60. View

Johns E, Singer B . Specificity of blockade of renal renin release by propranolol in the cat. Clin Sci Mol Med. 1974; 47(4):331-43. DOI: 10.1042/cs0470331. View

Buhler F, LARAGH J, Vaughan Jr E, Brunner H, Gavras H, Baer L . Antihypertensive action of propranolol. Specific antirenin responses in high and normal renin forms of essential, renal, renovascular and malignant hypertension. Am J Cardiol. 1973; 32(4):511-22. DOI: 10.1016/s0002-9149(73)80043-8. View

Buhler F, LARAGH J, Baer L, Vaughan Jr E, Brunner H . Propranolol inhibition of renin secretion. A specific approach to diagnosis and treatment of renin-dependent hypertensive diseases. N Engl J Med. 1972; 287(24):1209-14. DOI: 10.1056/NEJM197212142872401. View

Frohlich E, TARAZI R, DUSTAN H, PAGE I . The paradox of beta-adrenergic blockade in hypertension. Circulation. 1968; 37(3):417-23. DOI: 10.1161/01.cir.37.3.417. View

TARAZI R, DUSTAN H . Beta adrenergic blockade in hypertension. Practical and theoretical implications of long-term hemodynamic variations. Am J Cardiol. 1972; 29(5):633-40. DOI: 10.1016/0002-9149(72)90164-6. View

10.

Boyd G, FITZ A, Adamson A, Peart W . Radioimmunoassay determination of plasma-renin activity. Lancet. 1969; 1(7588):213-8. DOI: 10.1016/s0140-6736(69)91237-9. View

11.

Winer N, Chokshi D, Walkenhorst W . Effects of cyclic AMP, sympathomimetic amines, and adrenergic receptor antagonists on renin secretion. Circ Res. 1971; 29(3):239-48. DOI: 10.1161/01.res.29.3.239. View

12.

MICHELAKIS A, McALLISTER R . The effect of chronic adrenergic receptor blockade on plasma renin activity in man. J Clin Endocrinol Metab. 1972; 34(2):386-94. DOI: 10.1210/jcem-34-2-386. View

13.

DAY M, Roach A . -Adrenergic receptors in the central nervous system of the cat concerned with control of arterial blood pressure and heart rate. Nat New Biol. 1973; 242(114):30-1. DOI: 10.1038/newbio242030a0. View

14.

Julius S, Pascual A, ABBRECHT P, London R . Effect of beta-adrenergic blockade on plasma volume in human subjects. Proc Soc Exp Biol Med. 1972; 140(3):982-5. DOI: 10.3181/00379727-140-36594. View

15.

Hansson L, Zweifler A . The effct of propranolol on plasma renin activity and blood pressure in mild essential hypertension. Acta Med Scand. 1974; 195(5):397-401. DOI: 10.1111/j.0954-6820.1974.tb08159.x. View

16.

VANDONGEN R, Peart W, Boyd G . Andrenergic stimulation of renin secretion in the isolated perfused rat kidney. Circ Res. 1973; 32(2):290-6. DOI: 10.1161/01.res.32.2.290. View

17.

Amery A, Billiet L, Fagard R . Letter: Beta receptors and renin release. N Engl J Med. 1974; 290(5):284. DOI: 10.1056/NEJM197401312900516. View