Attractin (DPPT-L), a Member of the CUB Family of Cell Adhesion and Guidance Proteins, is Secreted by Activated Human T Lymphocytes and Modulates Immune Cell Interactions

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1998 Sep 16

PMID 9736737

Citations 44

Authors

J S Duke-Cohan

J Gu

D F McLaughlin

Y Xu

G J Freeman

S F Schlossman

Affiliations

Soon will be listed here.

Abstract

Attractin is a normal human serum glycoprotein of 175 kDa that is rapidly expressed on activated T cells and released extracellularly after 48-72 hr. We have cloned attractin and find that, as in its natural serum form, it mediates the spreading of monocytes that become the focus for the clustering of nonproliferating T lymphocytes. There are two mRNA species with hematopoietic tissue-specific expression that code for a 134-kDa protein with a putative serine protease catalytic serine, four EGF-like motifs, a CUB domain, a C type lectin domain, and a domain homologous with the ligand-binding region of the common gamma cytokine chain. Except for the latter two domains, the overall structure shares high homology with the Caenorhabditis elegans F33C8.1 protein, suggesting that attractin has evolved new domains and functions in parallel with the development of cell-mediated immunity.

Citing Articles

Plasma Proteomics Elucidated a Protein Signature in COVID-19 Patients with Comorbidities and Early-Diagnosis Biomarkers.

Urbiola-Salvador V, Lima de Souza S, Macur K, Czaplewska P, Chen Z Biomedicines. 2024; 12(4).

PMID: 38672194 PMC: 11048573. DOI: 10.3390/biomedicines12040840.

Immunohistochemical and Immunoelectron Microscopical Distribution of MEGF8 in the Mouse Central Nervous System.

Nakadate K, Kawakami K Cells. 2024; 13(1).

PMID: 38201267 PMC: 10778434. DOI: 10.3390/cells13010063.

A Large-Scale Exome-Wide Association Study Identifies Novel Germline Mutations in Lung Cancer.

Shen S, Li Z, Jiang Y, Duan W, Li H, Du S Am J Respir Crit Care Med. 2023; 208(3):280-289.

PMID: 37167549 PMC: 10395715. DOI: 10.1164/rccm.202212-2199OC.

Mutation of the attractin gene impairs working memory in rats.

Liu M, Xue C, Li X, Ding H, Zhang M, Chen K Brain Behav. 2023; 13(2):e2876.

PMID: 36621889 PMC: 9927853. DOI: 10.1002/brb3.2876.

Association between inflammation, reward processing, and ibuprofen-induced increases of miR-23b in astrocyte-enriched extracellular vesicles: A randomized, placebo-controlled, double-blind, exploratory trial in healthy individuals.

Burrows K, Figueroa-Hall L, Alarbi A, Stewart J, Kuplicki R, Tan C Brain Behav Immun Health. 2023; 27:100582.

PMID: 36605933 PMC: 9807827. DOI: 10.1016/j.bbih.2022.100582.

References

Morimoto C, Letvin N, Boyd A, Hagan M, Brown H, Kornacki M . The isolation and characterization of the human helper inducer T cell subset. J Immunol. 1985; 134(6):3762-9. View

Goldstein L, Dodt J, Howard L, Yeh Y, Tran H, Argraves W . Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease. J Biol Chem. 1997; 272(12):7595-601. DOI: 10.1074/jbc.272.12.7595. View

Hegen M, Niedobitek G, Klein C, STEIN H, Fleischer B . The T cell triggering molecule Tp103 is associated with dipeptidyl aminopeptidase IV activity. J Immunol. 1990; 144(8):2908-14. View

Rubartelli A, Cozzolino F, Talio M, Sitia R . A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence. EMBO J. 1990; 9(5):1503-10. PMC: 551842. DOI: 10.1002/j.1460-2075.1990.tb08268.x. View

Dang N, Torimoto Y, Deusch K, Schlossman S, Morimoto C . Comitogenic effect of solid-phase immobilized anti-1F7 on human CD4 T cell activation via CD3 and CD2 pathways. J Immunol. 1990; 144(11):4092-100. View

DAndrea A, Fasman G, Lodish H . A new hematopoietic growth factor receptor superfamily: structural features and implications for signal transduction. Curr Opin Cell Biol. 1990; 2(4):648-51. DOI: 10.1016/0955-0674(90)90106-o. View

Davis C . The many faces of epidermal growth factor repeats. New Biol. 1990; 2(5):410-9. View

Shimizu Y, Shaw S . Lymphocyte interactions with extracellular matrix. FASEB J. 1991; 5(9):2292-9. DOI: 10.1096/fasebj.5.9.1860621. View

Wada K, Yokotani N, Hunter C, Doi K, Wenthold R, Shimasaki S . Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family. Proc Natl Acad Sci U S A. 1992; 89(1):197-201. PMC: 48203. DOI: 10.1073/pnas.89.1.197. View

10.

Masuyama J, Berman J, Cruikshank W, Morimoto C, Center D . Evidence for recent as well as long term activation of T cells migrating through endothelial cell monolayers in vitro. J Immunol. 1992; 148(5):1367-74. View

11.

Mignatti P, Morimoto T, Rifkin D . Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endoplasmic reticulum-Golgi complex. J Cell Physiol. 1992; 151(1):81-93. DOI: 10.1002/jcp.1041510113. View

12.

Bork P, Beckmann G . The CUB domain. A widespread module in developmentally regulated proteins. J Mol Biol. 1993; 231(2):539-45. DOI: 10.1006/jmbi.1993.1305. View

13.

Miyamoto M, Naruo K, Seko C, Matsumoto S, Kondo T, Kurokawa T . Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property. Mol Cell Biol. 1993; 13(7):4251-9. PMC: 359975. DOI: 10.1128/mcb.13.7.4251-4259.1993. View

14.

Kameoka J, Tanaka T, Nojima Y, Schlossman S, Morimoto C . Direct association of adenosine deaminase with a T cell activation antigen, CD26. Science. 1993; 261(5120):466-9. DOI: 10.1126/science.8101391. View

15.

Tanaka T, Duke-Cohan J, Kameoka J, YARON A, Lee I, Schlossman S . Enhancement of antigen-induced T-cell proliferation by soluble CD26/dipeptidyl peptidase IV. Proc Natl Acad Sci U S A. 1994; 91(8):3082-6. PMC: 43519. DOI: 10.1073/pnas.91.8.3082. View

16.

Scanlan M, Raj B, Calvo B, Garin-Chesa P, Healey J, Old L . Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers. Proc Natl Acad Sci U S A. 1994; 91(12):5657-61. PMC: 44055. DOI: 10.1073/pnas.91.12.5657. View

17.

Xu Y, Slayter H . Immunocytochemical localization of endogenous anti-thrombin III in the vasculature of rat tissues reveals locations of anticoagulantly active heparan sulfate proteoglycans. J Histochem Cytochem. 1994; 42(10):1365-76. DOI: 10.1177/42.10.7930519. View

18.

Goldstein L, Ghersi G, Salamone M, Yeh Y, Flessate D, Chen W . Molecular cloning of seprase: a serine integral membrane protease from human melanoma. Biochim Biophys Acta. 1997; 1361(1):11-9. DOI: 10.1016/s0925-4439(97)00032-x. View

19.

Proost P, De Meester I, Schols D, Struyf S, Lambeir A, Wuyts A . Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection. J Biol Chem. 1998; 273(13):7222-7. DOI: 10.1074/jbc.273.13.7222. View

20.

Ridge J, Rosa F, Matzinger P . A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature. 1998; 393(6684):474-8. DOI: 10.1038/30989. View