Trisomy 3 is Not a Common Feature in Malignant Lymphomas of Mucosa-associated Lymphoid Tissue Type

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 1998 Sep 15

PMID 9736018

Citations 14

Authors

G Ott

J Kalla

A Steinhoff

A Rosenwald

T Katzenberger

U Roblick

M M Ott

H K Muller-Hermelink

Affiliations

Soon will be listed here.

Abstract

The genetic background of extranodal marginal zone B-cell non-Hodgkin's lymphoma (NHL) of mucosa-associated lymphoid tissue (MALT) type is poorly understood. In contrast to most entities of primary nodal lymphomas, few cytogenetic data are available, and gene rearrangements frequently encountered in and highly characteristic of certain entities of systemic NHL are absent in this type of lymphoma. Recently, it was suggested that MALT-type NHLs are associated with certain numerical chromosome aberrations and especially with trisomy 3. We performed an extensive study using a sensitive double (bicolor) fluorescence in situ hybridization technique for the analysis of trisomies for chromosomes 3, 7, 12, and 18 in 60 samples of low-grade and 45 high-grade MALT-type tumors. In the low-grade cases, trisomy 3 was found in a frequency of only 20%. High-grade lymphomas of MALT type were associated with trisomies 3, 7, 12, and 18 in 36, 20, 18, and 13% of the cases, respectively. Whereas no difference was encountered for trisomy 3 in primary and secondary/simultaneous high-grade lymphomas, +7 and +12 were associated with primary lymphomas, and a +18 was predominantly found in secondary/simultaneous high-grade NHL. These results challenge earlier reports describing a high frequency of +3 in low-grade MALT-type NHL and indicate a possibly different genetic evolution pattern of primary and secondary/simultaneous high-grade lymphomas of primary mucosal origin.

Citing Articles

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References

Kerrigan D, Irons J, Chen I . bcl-2 gene rearrangement in salivary gland lymphoma. Am J Surg Pathol. 1990; 14(12):1133-8. DOI: 10.1097/00000478-199012000-00005. View

Barth T, Dohner H, WERNER C, Stilgenbauer S, Schlotter M, Pawlita M . Characteristic pattern of chromosomal gains and losses in primary large B-cell lymphomas of the gastrointestinal tract. Blood. 1998; 91(11):4321-30. View

Haaf T, Schmid M . Chromosome topology in mammalian interphase nuclei. Exp Cell Res. 1991; 192(2):325-32. DOI: 10.1016/0014-4827(91)90048-y. View

Hopman A, van Hooren E, Van De Kaa C, Vooijs P, Ramaekers F . Detection of numerical chromosome aberrations using in situ hybridization in paraffin sections of routinely processed bladder cancers. Mod Pathol. 1991; 4(4):503-13. View

Wotherspoon A, Pan L, Diss T, Isaacson P . Cytogenetic study of B-cell lymphoma of mucosa-associated lymphoid tissue. Cancer Genet Cytogenet. 1992; 58(1):35-8. DOI: 10.1016/0165-4608(92)90130-z. View

Clark H, Jones D, Wright D . Cytogenetic and molecular studies of t(14;18) and t(14;19) in nodal and extranodal B-cell lymphoma. J Pathol. 1992; 166(2):129-37. DOI: 10.1002/path.1711660208. View

Griffin C, Zehnbauer B, Beschorner W, Ambinder R, Mann R . t(11;18)(q21;q21) is a recurrent chromosome abnormality in small lymphocytic lymphoma. Genes Chromosomes Cancer. 1992; 4(2):153-7. DOI: 10.1002/gcc.2870040209. View

Horsman D, Gascoyne R, Klasa R, Coupland R . t(11;18)(q21;q21.1): a recurring translocation in lymphomas of mucosa-associated lymphoid tissue (MALT)?. Genes Chromosomes Cancer. 1992; 4(2):183-7. DOI: 10.1002/gcc.2870040213. View

Vourch C, Taruscio D, Boyle A, Ward D . Cell cycle-dependent distribution of telomeres, centromeres, and chromosome-specific subsatellite domains in the interphase nucleus of mouse lymphocytes. Exp Cell Res. 1993; 205(1):142-51. DOI: 10.1006/excr.1993.1068. View

10.

Ferrari S, Grande A, Zucchini P, Manfredini R, Tagliafico E, Rossi E . Overexpression of c-kit in a leukemic cell population carrying a trisomy 4 and its relationship with the proliferative capacity. Leuk Lymphoma. 1993; 9(6):495-501. DOI: 10.3109/10428199309145756. View

11.

Leroux D, SEITE P, Hillion J, Le Marchadour F, Pegourie-Bandelier B, Jacob M . t(11;18)(q21;q21) may delineate a spectrum of diffuse small B-cell lymphoma with extranodal involvement. Genes Chromosomes Cancer. 1993; 7(1):54-6. DOI: 10.1002/gcc.2870070109. View

12.

Hussell T, Isaacson P, Crabtree J, Spencer J . The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori. Lancet. 1993; 342(8871):571-4. DOI: 10.1016/0140-6736(93)91408-e. View

13.

Oscier D, Matutes E, Gardiner A, Glide S, Mould S, Brito-Babapulle V . Cytogenetic studies in splenic lymphoma with villous lymphocytes. Br J Haematol. 1993; 85(3):487-91. DOI: 10.1111/j.1365-2141.1993.tb03337.x. View

14.

Greiner A, Marx A, Heesemann J, Leebmann J, Schmausser B, Muller-Hermelink H . Idiotype identity in a MALT-type lymphoma and B cells in Helicobacter pylori associated chronic gastritis. Lab Invest. 1994; 70(4):572-8. View

15.

Harris N, Jaffe E, STEIN H, Banks P, Chan J, Cleary M . A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood. 1994; 84(5):1361-92. View

16.

Visakorpi T, Hyytinen E, Kallioniemi A, Isola J, Kallioniemi O . Sensitive detection of chromosome copy number aberrations in prostate cancer by fluorescence in situ hybridization. Am J Pathol. 1994; 145(3):624-30. PMC: 1890337. View

17.

Schlegelberger B, Zhang Y, Grote W . Detection of aberrant clones in nearly all cases of angioimmunoblastic lymphadenopathy with dysproteinemia-type T-cell lymphoma by combined interphase and metaphase cytogenetics. Blood. 1994; 84(8):2640-8. View

18.

Whang-Peng J, Knutsen T, Jaffe E, Raffeld M, Zhao W, Duffey P . Cytogenetic study of two cases with lymphoma of mucosa-associated lymphoid tissue. Cancer Genet Cytogenet. 1994; 77(1):74-80. DOI: 10.1016/0165-4608(94)90153-8. View

19.

Hogemann I, Bock S, Heppner P, Petrides P . Cytogenetic and growth factor gene analysis of a renal carcinoma cell line. Cancer Genet Cytogenet. 1994; 78(2):175-80. DOI: 10.1016/0165-4608(94)90087-6. View

20.

Wotherspoon A, Finn T, Isaacson P . Trisomy 3 in low-grade B-cell lymphomas of mucosa-associated lymphoid tissue. Blood. 1995; 85(8):2000-4. View