Use of the Malthus-AT System to Assess the Efficacy of Permeabilizing Agents on the Activity of Antibacterial Agents Against Pseudomonas Aeruginosa

Overview

Journal Lett Appl Microbiol

Publisher Oxford University Press

Specialty Microbiology

Date 1998 Aug 26

PMID 9717312

Citations 3

Authors

H M Ayres

D N Payne

J R Furr

A D Russell

Affiliations

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Abstract

The Malthus-AT system provided a satisfactory method for examining the effects of permeabilizing agents on the activity of sub-inhibitory concentrations of antibacterial agents against Pseudomonas aeruginosa G48. Under this system, disodium edetate potentiated the activity of chlorhexidine diacetate (CHA), cetylpyridinium chloride, para-chlorometaxylenol and triclosan. Nitrilotriacetic acid enhanced the activity of some of the antibacterials tested, whereas sodium polyphosphate markedly reduced the efficacy of CHA.

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