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A Proinflammatory Factor in Lymphocytes. Its Role in the Development of Acute, Non-immunological Inflammatory Reactions

Overview
Journal Br J Exp Pathol
Specialty Pathology
Date 1976 Aug 1
PMID 971405
Citations 19
Authors
J G LEME
G H Bechara
R R Dos Santos
Affiliations
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Abstract

Drug-induced leucopenia renders rats hyporeactive to various inflammatory stimuli. Administration to leucopenic rats of suspensions of lymphocytes, sufficient to apparently correct the induced lymphocytopenia, led to a partial but marked reversal of the inhibited responses. Similar results were observed when lysates of lymphocytes or filtrates of the disintegrated cells were injected. Suspensions of polymorphonuclear granulocytes, on the contrary, were ineffective in producing a reversal of inhibited inflammatory reactions in leucopenic rats. The presence of a proinflammatory factor (LpIF) in lymphocytes, which might be involved in the modulation of acute inflammatory responses is suggested.

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