Pouchitis

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 1998 Aug 15

PMID 9705605

Citations 3

Authors

W R Schouten

Affiliations

Soon will be listed here.

Abstract

Pouchitis is a major long-term complication of the continent ileostomy as well as the ileoanal pouch anastomosis. When diagnosed on the basis of clinical, endoscopic and histologic features, this syndrome has been demonstrated almost exclusively in patients with ulcerative colitis. The clinical course, the endoscopic findings and the histologic abnormalities resemble those of ulcerative colitis. The association with extra-intestinal manifestations further supports the hypothesis that pouchitis represents ulcerative colitis in the small bowel. All ileal reservoirs show bacterial overgrowth, especially of anaerobes. As a response to this altered intraluminal environment chronic inflammation and incomplete colonic metaplasia occur. The efficiency of metronidazole does suggest that bacteriological factors play an important role in the pathogenesis of pouchitis.

Citing Articles

Alicaforsen: An Emerging Therapeutic Agent for Ulcerative Colitis and Refractory Pouchitis.

Hosten T, Zhao K, Han H, Liu G, He X Gastroenterology Res. 2014; 7(2):51-55.

PMID: 27785270 PMC: 5051075. DOI: 10.14740/gr599w.

Inflammatory pouch disease: The spectrum of pouchitis.

Zezos P, Saibil F World J Gastroenterol. 2015; 21(29):8739-52.

PMID: 26269664 PMC: 4528017. DOI: 10.3748/wjg.v21.i29.8739.

FK506-Binding Protein 5 mRNA Levels in Ileal Mucosa Are Associated with Pouchitis in Patients with Ulcerative Colitis.

Araki T, Kawamura M, Tanaka K, Okita Y, Fujikawa H, Uchida K Dig Dis Sci. 2015; 60(6):1617-23.

PMID: 25596721 DOI: 10.1007/s10620-015-3528-9.

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