The Function of Auxiliary Operators

Overview

Journal Mol Microbiol

Specialties Microbiology
Molecular Biology

Date 1998 Aug 14

PMID 9701798

Citations 25

Authors

B Muller-Hill

Affiliations

Soon will be listed here.

Abstract

Gene regulation by control of transcription has been analysed in great detail both in prokaryotes and in eukaryotes. The frequency of transcription may be decreased by repressors or increased by activators. A repressor may work by decreasing the concentration of RNA polymerase at a promoter capable of forming an open complex. An activator may work by increasing the concentration of RNA polymerase at a promoter capable of forming an open complex. For this purpose, a strategy is used over and over again. It is called increase in local concentration. How Escherichia coli uses this strategy efficiently is discussed.

Citing Articles

Engineered transcription activator-like effector dimer proteins confer DNA loop-dependent gene repression comparable to Lac repressor.

Becker N, Peters J, Lewis E, Daby C, Clark K, Maher 3rd L Nucleic Acids Res. 2024; 52(16):9996-10004.

PMID: 39077947 PMC: 11381355. DOI: 10.1093/nar/gkae656.

Characterization of Gene Repression by Designed Transcription Activator-like Effector Dimer Proteins.

Becker N, Peters J, Schwab T, Phillips W, Wallace J, Clark K Biophys J. 2020; 119(10):2045-2054.

PMID: 33091377 PMC: 7732741. DOI: 10.1016/j.bpj.2020.10.007.

Regulation of alginate catabolism involves a GntR family repressor in the marine flavobacterium Zobellia galactanivorans DsijT.

Dudek M, Dieudonne A, Jouanneau D, Rochat T, Michel G, Sarels B Nucleic Acids Res. 2020; 48(14):7786-7800.

PMID: 32585009 PMC: 7641319. DOI: 10.1093/nar/gkaa533.

Homolog comparisons further reconcile in vitro and in vivo correlations of protein activities by revealing over-looked physiological factors.

Tungtur S, Schwingen K, Riepe J, Weeramange C, Swint-Kruse L Protein Sci. 2019; 28(10):1806-1818.

PMID: 31351028 PMC: 6739814. DOI: 10.1002/pro.3695.

Transcriptome Analysis of Polyhydroxybutyrate Cycle Mutants Reveals Discrete Loci Connecting Nitrogen Utilization and Carbon Storage in .

DAlessio M, Nordeste R, Doxey A, Charles T mSystems. 2017; 2(5).

PMID: 28905000 PMC: 5596199. DOI: 10.1128/mSystems.00035-17.