Investigation of the Effect of PhTx2, from the Venom of the Spider Phoneutria Nigriventer, on the Release of [3H]-acetylcholine from Rat Cerebrocortical Synaptosomes

Overview

Journal Toxicon

Specialty Toxicology

Date 1998 Aug 5

PMID 9690785

Citations 4

Authors

J R Moura

M A Prado

M V Gomez

E Kalapothakis

C R DINIZ

M N Cordeiro

M A Romano-Silva

Affiliations

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Abstract

Venoms from spiders are an important source of toxins that can help on the dissection of mechanisms involved in neurotransmission. Among them is the venom of the spider Phoneutria nigriventer that contains several toxic fractions with different targets in mammals and/or insects. We here report that one of these fractions (PhTx2) is able to evoke acetylcholine release from rat cortical synaptosomes and that this effect is dependent on extracellular calcium and is inhibited by the sodium channel blocker tetrodotoxin.

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Transcriptomic Analysis of the Venom Gland and Enzymatic Characterization of the Venom of (Ctenidae) from Colombia.

Vasquez-Escobar J, Romero-Gutierrez T, Morales J, Clement H, Corzo G, Benjumea D Toxins (Basel). 2022; 14(5).

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Partial Characterization of Venom from the Colombian Spider Phoneutria Boliviensis (Aranae:Ctenidae).

Estrada-Gomez S, Vargas Munoz L, Lanchero P, Segura Latorre C Toxins (Basel). 2015; 7(8):2872-87.

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Nitric oxide-induced vasorelaxation in response to PnTx2-6 toxin from Phoneutria nigriventer spider in rat cavernosal tissue.

Nunes K, Cordeiro M, Richardson M, Borges M, Diniz S, Cardoso V J Sex Med. 2010; 7(12):3879-88.

PMID: 20722794 PMC: 3022477. DOI: 10.1111/j.1743-6109.2010.01978.x.

Tx2-6 toxin of the Phoneutria nigriventer spider potentiates rat erectile function.

Nunes K, Costa-Goncalves A, Lanza L, Cortes S, Cordeiro M, Richardson M Toxicon. 2008; 51(7):1197-206.

PMID: 18397797 PMC: 3019117. DOI: 10.1016/j.toxicon.2008.02.010.

Phoneutria nigriventer venom: a cocktail of toxins that affect ion channels.

Gomez M, Kalapothakis E, Guatimosim C, Prado M Cell Mol Neurobiol. 2003; 22(5-6):579-88.

PMID: 12585681 PMC: 11533758. DOI: 10.1023/a:1021836403433.