Transformation of the Ionic X-ray Contrast Agent Diatrizoate and Related Triiodinated Benzoates by Trametes Versicolor

Overview

Journal Appl Environ Microbiol

Specialties Environmental Health
Microbiology

Date 1998 Aug 4

PMID 9687487

Citations 1

Authors

U Rode

R Muller

Affiliations

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Abstract

Iodinated X-ray contrast agents are considered to be nondegradable by microorganisms. The decomposition of the ionic X-ray contrast agents Diatrizoate (3,5-di(acetamido)-2,4,6-triiodobenzoic acid) and Iodipamide (3,3'-adipoyl-diimino-di(2,4,6-triiodobenzoic acid) and related triiodinated benzoates (Acetrizoate [3-acetylamino-2,4, 6-triiodobenzoic acid] and Aminotrizoate [3-amino-2,4, 6-triiodobenzoic acid]) by Trametes versicolor has been investigated. The fungus was able to transform all tested triiodinated benzoates cometabolically. During transformation of these compounds, iodide was released, but deiodination was not complete. T. versicolor liberated traces of 14CO2 from uniformly ring-14C-labeled Diatrizoate (3,5-di(acetamido)-2,4,6-triiodobenzoate). Various extracellular metabolites were detected during transformation of the different substances. In the transformation of Diatrizoate, the three main metabolites were identified as 3,5-di(acetamido)-2, 6-diiodobenzoic acid, 3,5-di(acetamido)-2,4-diiodobenzoic acid, and 3,5-di(acetamido)-2-iodobenzoic acid, suggesting reductive deiodinations in steps as initial transformation steps.

Citing Articles

Untapped potential: exploiting fungi in bioremediation of hazardous chemicals.

Harms H, Schlosser D, Wick L Nat Rev Microbiol. 2011; 9(3):177-92.

PMID: 21297669 DOI: 10.1038/nrmicro2519.

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