Alternative Pathway Therapy for Urea Cycle Disorders

Overview

Journal J Inherit Metab Dis

Publisher Wiley

Date 1998 Aug 1

PMID 9686348

Citations 25

Authors

F Feillet

J V Leonard

Affiliations

Soon will be listed here.

Abstract

In man the major pathway for the disposal of waste nitrogen is the urea cycle; in inborn errors of this pathway, nitrogen flux is reduced. As a result there is accumulation of ammonia and glutamine with disordered metabolism of other amino acids. Nitrogen homeostasis can be restored in these patients with a low-protein diet combined with compounds that create alternative pathways for nitrogen excretion. The introduction of these compounds has been a major advance in the management of these inborn errors and as a result the outcome, particularly for those treated early, has improved.

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