Brain-derived Neurotrophic Factor Rapidly Potentiates Synaptic Transmission Through NMDA, but Suppresses It Through Non-NMDA Receptors in Rat Hippocampal Neuron

Overview

Journal Brain Res

Specialty Neurology

Date 1998 Jul 17

PMID 9666119

Citations 12

Authors

D K Song

B Choe

J H Bae

W K Park

I S Han

W K Ho

Y E Earm

Affiliations

Soon will be listed here.

Abstract

Brain-derived neurotrophic factor (BDNF) rapidly enhances synaptic transmission among the hippocampal neurons. In order to examine which component of glutamate receptors participates in synaptic potentiation by BDNF, we have studied the effect of glutamate antagonists on excitatory postsynaptic currents (EPSCs) enhanced by BDNF, using cultured embryonic hippocampal neurons. In the presence of AP5, a N-methyl-D-aspartate (NMDA) antagonist, BDNF depressed the EPSCs. In contrast, BDNF enhanced the EPSCs in the presence of a non-NMDA antagonist CNQX. Our results suggest that BDNF acutely activates synaptic transmission via NMDA, but suppresses it via non-NMDA receptors in the hippocampus.

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