Sperm Penetration Assay in Predicting Successful in Vitro Fertilization. A Meta-analysis

Overview

Journal J Reprod Med

Specialties Gynecology & Obstetrics
Reproductive Medicine

Date 1998 Jul 8

PMID 9653696

Citations 3

Authors

B W Mol

S Meijer

S Yuppa

E Tan

J de Vries

P M Bossuyt

F van der Veen

Affiliations

Soon will be listed here.

Abstract

Objective: To determine if the performance of the sperm penetration assay (SPA) is useful in predicting successful in vitro fertilization (IVF).

Methods: A meta-analysis was set up to determine the performance of SPA in the prediction of IVF success. We collected data on 647 patients in 24 studies. For each study, a two-by-two table was constructed from the results of SPA and IVF.

Results: The sensitivity and specificity of SPA as compared to IVF were heterogeneous. A summary receiver operating characteristics curve could be estimated, showing that the sensitivity of SPA was only 37%, with a specificity of 95%. Subgroup analysis did not explain the lack of homogeneity.

Conclusion: Since withholding IVF inappropriately has major consequences, performing SPA is insufficient for selecting patients for treatment with IVF-embryo transfer.

Citing Articles

The hamster egg penetration test may decrease intracytoplasmic sperm injection utilization while maintaining high conventional fertilization rates.

Ibrahim Y, Einerson B, Carrell D, Emery B, Johnstone E Asian J Androl. 2020; 23(1):11-15.

PMID: 32436865 PMC: 7831835. DOI: 10.4103/aja.aja_18_20.

Sperm function tests in clinical practice.

Kizilay F, Altay B Turk J Urol. 2017; 43(4):393-400.

PMID: 29201498 PMC: 5687198. DOI: 10.5152/tud.2017.96646.

Hemizona assay and sperm penetration assay in the prediction of IVF outcome: a systematic review.

Vogiatzi P, Chrelias C, Cahill D, Creatsa M, Vrachnis N, Iliodromiti Z Biomed Res Int. 2013; 2013:945825.

PMID: 24228261 PMC: 3818817. DOI: 10.1155/2013/945825.