Transcriptional Control: Tat Cofactors and Transcriptional Elongation

Overview

Journal Curr Biol

Publisher Cell Press

Specialty Biology

Date 1998 Jul 4

PMID 9651670

Citations 13

Authors

K Yankulov

D Bentley

Affiliations

Soon will be listed here.

Abstract

HIV-1 gene expression requires the transactivator Tat, which stimulates viral transcript elongation. Recent results show that two cellular cyclin-dependent kinases, which phosphorylate the carboxy-terminal domain of the RNA polymerase II large subunit, contact Tat and contribute to the control of transcriptional elongation.

Citing Articles

Role of Divalent Cations in HIV-1 Replication and Pathogenicity.

Khan N, Chen X, Geiger J Viruses. 2020; 12(4).

PMID: 32326317 PMC: 7232465. DOI: 10.3390/v12040471.

Ready, pause, go: regulation of RNA polymerase II pausing and release by cellular signaling pathways.

Liu X, Kraus W, Bai X Trends Biochem Sci. 2015; 40(9):516-25.

PMID: 26254229 PMC: 4553066. DOI: 10.1016/j.tibs.2015.07.003.

Impact of Tat Genetic Variation on HIV-1 Disease.

Li L, Dahiya S, Kortagere S, Aiamkitsumrit B, Cunningham D, Pirrone V Adv Virol. 2012; 2012:123605.

PMID: 22899925 PMC: 3414192. DOI: 10.1155/2012/123605.

Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription.

Zhou M, Deng L, Lacoste V, Park H, Pumfery A, Kashanchi F J Virol. 2004; 78(24):13522-33.

PMID: 15564463 PMC: 533906. DOI: 10.1128/JVI.78.24.13522-13533.2004.

The Tat/TAR-dependent phosphorylation of RNA polymerase II C-terminal domain stimulates cotranscriptional capping of HIV-1 mRNA.

Zhou M, Deng L, Kashanchi F, Brady J, Shatkin A, Kumar A Proc Natl Acad Sci U S A. 2003; 100(22):12666-71.

PMID: 14569024 PMC: 240675. DOI: 10.1073/pnas.1835726100.