Identification of Multispecific Organic Anion Transporter 2 Expressed Predominantly in the Liver

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 1998 Jul 3

PMID 9650585

Citations 52

Authors

T Sekine

S H Cha

M Tsuda

N Apiwattanakul

N Nakajima

Y Kanai

H Endou

Affiliations

Soon will be listed here.

Abstract

In the present study, we demonstrate that NLT (novel liver-specific transport protein) is a multispecific organic anion transporter of the liver. The amino acid sequence of NLT shows 42% identity to that of the renal multispecific organic anion transporter, OAT1. When expressed in Xenopus laevis oocytes, NLT mediated uptake of organic anions, such as salicylate, acetylsalicylate, PGE2, dicarboxylates and p-aminohippurate. [14C]Salicylate uptake via NLT was saturable (Km = 88.8 +/- 23.4 microM) and sodium-independent. Expression of the mRNA of NLT was detected in the liver and kidney (liver >> kidney). We propose that NLT be renamed OAT2.

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