Pharmacokinetics and Pharmacodynamics of Alprenolol in the Treatment of Hypertension. II. Relationship to Its Effect on Blood Pressure and Plasma Renin Activity

Overview

Journal Eur J Clin Pharmacol

Specialty Pharmacology

Date 1976 Jun 15

PMID 964292

Citations 14

Authors

P Collste

K Haglund

M Frisk-Holmberg

M L Orme

M D Rawlins

J Ostman

Affiliations

Soon will be listed here.

Abstract

The kinetics of alprenolol, in relation to its effect on blood pressure and plasma renin activity, have been studied in sixteen patients. A within-patient comparison was made between therapy for six weeks with placebo or alpronolol 200 mg thrice daily. Thirteen patients responded to alprenolol by a signoficant fall in blood pressure. In three other patients treatment did not lower blood pressure. In the group as a whole there was no significant correlation between the fall in systolic, diastolic or mean blood pressure, and the steady-state plasma alprenolol concentration, renin status, or degree of beta blockade. However, the thirteen responsive patients showed a significant relationship (p less than 0.05 - 0.001) between the log mean steady-state plasma alprenolol concentration and the hypotensive response.

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