Binding of Four Sulphonamides to Human Albumin

Overview

Journal Eur J Clin Pharmacol

Specialty Pharmacology

Date 1976 Jun 15

PMID 964290

Citations 10

Authors

R Zini

P dAthis

A Hoareau

J P Tillement

Affiliations

Soon will be listed here.

Abstract

The four sulphonamides studied--furosemide, tolbutamide, sulfafurazole and sulfonamidochlorobenzoic acid--bind to human albumin at the same sites but with decreasing affinity. These sites are also common to other drugs, namely acenocoumarin, chlorophenoxyisobutyric acid, phenylbutazone and warfarin. In plasma, the four sulphonamides considered bind mainly to albumin, but also, at higher concentrations, to globulins, to an extent that increases as their affinity for albumin lessens.

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