JAK/STAT Signaling by Cytokine Receptors

Overview

Journal Curr Opin Immunol

Publisher Elsevier

Specialty Allergy & Immunology

Date 1998 Jun 25

PMID 9638363

Citations 53

Authors

K D Liu

S L Gaffen

M A Goldsmith

Affiliations

Soon will be listed here.

Abstract

The JAK/STAT pathway is recognized as one of the major mechanisms by which cytokine receptors transduce intracellular signals. This system is regulated at multiple levels, including JAK activation, nuclear trafficking of STAT factors, and negative feedback loops. Gene deletion studies have implicated selected STAT factors as predominant mediators for a limited number of lymphokines. This signaling pathway influences normal cell survival and growth mechanisms and may contribute to oncogenic transformation.

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