Multiple Domains for Initiator Binding Proteins TFII-I and YY-1 Are Present in the Initiator and Upstream Regions of the Rat XDH/XO TATA-less Promoter

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 1998 May 21

PMID 9592172

Citations 5

Authors

M P Clark

C W Chow

J E Rinaldo

R Chalkley

Affiliations

Soon will be listed here.

Abstract

We previously reported that the TATA-less rat xanthine dehydrogenase/oxidase (XDH/XO) promoter is organized with multiple initiator elements (Inr 1, 2, 3 and 4). Additionally, we identified six factor binding footprints in the upstream region of this promoter (FP 1-FP 6), two of which (FP 2 and FP 4) we showed to be C/EBP binding sites. In this report we continue our characterization of the XDH/XO promoter, detailing other cis elements which comprise the Inr and upstream binding factors. Interestingly, multiple binding domains for known initiator binding proteins, YY-1 and USF-related factor/TFII-I, have been identified which potentially play an important role in transcription initiation.

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