Soluble L-selectin Concentration in Bronchoalveolar Lavage Fluid Obtained from Infants Who Develop Chronic Lung Disease of Prematurity

Overview

Journal Arch Dis Child Fetal Neonatal Ed

Specialties Gynecology & Obstetrics
Pediatrics

Date 1998 May 13

PMID 9577287

Citations 8

Authors

S Kotecha

M Silverman

R J Shaw

N Klein

Affiliations

Soon will be listed here.

Abstract

Aims: To explore the changes in neutrophil adhesion molecule expression and release into bronchoalveolar lavage fluid (BAL) obtained from infants who developed chronic lung disease (CLD).

Methods: BAL fluid was obtained from 37 infants: 18 (median gestation 26 weeks, birthweight 835 g) who developed CLD, 12 (29 weeks, 1345 g) with respiratory distress syndrome (RDS) and seven control infants (33 weeks, 2190 g).

Results: Soluble L-selectin (sL-selectin) in BAL fluid from the CLD and non-CLD groups was similar immediately after birth, but in infants who subsequently developed CLD, sL-selectin remained persistently increased (at day 7: CLD 42.6 vs RDS 6.0 ng/ml, p < 0.05; CLD vs controls 1.5 ng/ml; p < 0.05). CD11b/CD18 expression on neutrophils obtained by BAL increased with time to reach a maximum at 17 days of age in infants who developed CLD.

Conclusions: These results suggest that leucocyte traffic persists in infants who develop CLD and may have an important part to play in the pathogenesis of CLD.

Citing Articles

L-Selectin/CD62L is a Key Driver of Non-Alcoholic Steatohepatitis in Mice and Men.

Drescher H, Schippers A, Rosenhain S, Gremse F, Bongiovanni L, de Bruin A Cells. 2020; 9(5).

PMID: 32365632 PMC: 7290433. DOI: 10.3390/cells9051106.

Biomarkers in Pediatric ARDS: Future Directions.

Orwoll B, Sapru A Front Pediatr. 2016; 4:55.

PMID: 27313995 PMC: 4887507. DOI: 10.3389/fped.2016.00055.

Efficacy of Leukadherin-1 in the Prevention of Hyperoxia-Induced Lung Injury in Neonatal Rats.

Jagarapu J, Kelchtermans J, Rong M, Chen S, Hehre D, Hummler S Am J Respir Cell Mol Biol. 2015; 53(6):793-801.

PMID: 25909334 PMC: 4742935. DOI: 10.1165/rcmb.2014-0422OC.

Ventilator-induced lung injury in preterm infants.

Carvalho C, Silveira R, Procianoy R Rev Bras Ter Intensiva. 2014; 25(4):319-26.

PMID: 24553514 PMC: 4031878. DOI: 10.5935/0103-507X.20130054.

Correlation between serum caffeine levels and changes in cytokine profile in a cohort of preterm infants.

Valdez R, Ahlawat R, Wills-Karp M, Nathan A, Ezell T, Gauda E J Pediatr. 2010; 158(1):57-64, 64.e1.

PMID: 20691455 PMC: 3985280. DOI: 10.1016/j.jpeds.2010.06.051.

References

Bancalari E, Abdenour G, FELLER R, Gannon J . Bronchopulmonary dysplasia: clinical presentation. J Pediatr. 1979; 95(5 Pt 2):819-23. DOI: 10.1016/s0022-3476(79)80442-4. View

Symon F, Wardlaw A . Selectins and their counter receptors: a bitter sweet attraction. Thorax. 1996; 51(11):1155-7. PMC: 1090529. DOI: 10.1136/thx.51.11.1155. View

Rennard S, Ghafouri M, Thompson A, Linder J, Vaughan W, Jones K . Fractional processing of sequential bronchoalveolar lavage to separate bronchial and alveolar samples. Am Rev Respir Dis. 1990; 141(1):208-17. DOI: 10.1164/ajrccm/141.1.208. View

Doerschuk C, Winn R, Coxson H, Harlan J . CD18-dependent and -independent mechanisms of neutrophil emigration in the pulmonary and systemic microcirculation of rabbits. J Immunol. 1990; 144(6):2327-33. View

Seth R, RAYMOND F, Makgoba M . Circulating ICAM-1 isoforms: diagnostic prospects for inflammatory and immune disorders. Lancet. 1991; 338(8759):83-4. DOI: 10.1016/0140-6736(91)90077-3. View

Murch S, MacDonald T, Wood C, Costeloe K . Tumour necrosis factor in the bronchoalveolar secretions of infants with the respiratory distress syndrome and the effect of dexamethasone treatment. Thorax. 1992; 47(1):44-7. PMC: 463556. DOI: 10.1136/thx.47.1.44. View

Hogg N . Roll, roll, roll your leucocyte gently down the vein. Immunol Today. 1992; 13(4):113-5. DOI: 10.1016/0167-5699(92)90103-E. View

Grigg J, Arnon S, Silverman M . Fractional processing of sequential bronchoalveolar lavage fluid from intubated babies. Eur Respir J. 1992; 5(6):727-32. View

Arnon S, Grigg J, Silverman M . Pulmonary inflammatory cells in ventilated preterm infants: effect of surfactant treatment. Arch Dis Child. 1993; 69(1 Spec No):44-8. PMC: 1029397. DOI: 10.1136/adc.69.1_spec_no.44. View

10.

Zetterberg E, Richter J . Correlation between serum level of soluble L-selectin and leukocyte count in chronic myeloid and lymphocytic leukemia and during bone marrow transplantation. Eur J Haematol. 1993; 51(2):113-9. DOI: 10.1111/j.1600-0609.1993.tb01603.x. View

11.

Shijubo N, Imai K, Shigehara K, Honda Y, Koba H, Tsujisaki M . Soluble intercellular adhesion molecule-1 (ICAM-1) in sera and bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis. Clin Exp Immunol. 1994; 95(1):156-61. PMC: 1534644. DOI: 10.1111/j.1365-2249.1994.tb06030.x. View

12.

Groneck P, Oppermann M, Eiffert H, Speer C . Association of pulmonary inflammation and increased microvascular permeability during the development of bronchopulmonary dysplasia: a sequential analysis of inflammatory mediators in respiratory fluids of high-risk preterm neonates. Pediatrics. 1994; 93(5):712-8. View

13.

Donnelly S, Haslett C, Dransfield I, Robertson C, Carter D, Ross J . Role of selectins in development of adult respiratory distress syndrome. Lancet. 1994; 344(8917):215-9. DOI: 10.1016/s0140-6736(94)92995-5. View

14.

Bagchi A, Viscardi R, Taciak V, Ensor J, McCrea K, Hasday J . Increased activity of interleukin-6 but not tumor necrosis factor-alpha in lung lavage of premature infants is associated with the development of bronchopulmonary dysplasia. Pediatr Res. 1994; 36(2):244-52. DOI: 10.1203/00006450-199408000-00017. View

15.

Kotecha S, Chan B, Azam N, Silverman M, Shaw R . Increase in interleukin-8 and soluble intercellular adhesion molecule-1 in bronchoalveolar lavage fluid from premature infants who develop chronic lung disease. Arch Dis Child Fetal Neonatal Ed. 1995; 72(2):F90-6. PMC: 2528395. DOI: 10.1136/fn.72.2.f90. View

16.

Kotecha S, Wangoo A, Silverman M, Shaw R . Increase in the concentration of transforming growth factor beta-1 in bronchoalveolar lavage fluid before development of chronic lung disease of prematurity. J Pediatr. 1996; 128(4):464-9. DOI: 10.1016/s0022-3476(96)70355-4. View

17.

Walcheck B, Kahn J, Fisher J, Wang B, Fisk R, Payan D . Neutrophil rolling altered by inhibition of L-selectin shedding in vitro. Nature. 1996; 380(6576):720-3. DOI: 10.1038/380720a0. View

18.

Haught W, Mansour M, Rothlein R, Kishimoto T, Mainolfi E, Hendricks J . Alterations in circulating intercellular adhesion molecule-1 and L-selectin: further evidence for chronic inflammation in ischemic heart disease. Am Heart J. 1996; 132(1 Pt 1):1-8. DOI: 10.1016/s0002-8703(96)90383-x. View

19.

Kotecha S, Wilson L, Wangoo A, Silverman M, Shaw R . Increase in interleukin (IL)-1 beta and IL-6 in bronchoalveolar lavage fluid obtained from infants with chronic lung disease of prematurity. Pediatr Res. 1996; 40(2):250-6. DOI: 10.1203/00006450-199608000-00010. View

20.

Murch S, Costeloe K, Klein N, MacDonald T . Early production of macrophage inflammatory protein-1 alpha occurs in respiratory distress syndrome and is associated with poor outcome. Pediatr Res. 1996; 40(3):490-7. DOI: 10.1203/00006450-199609000-00020. View