Gardimycin, a New Antibiotic from Actinoplanes. I. Description of the Producer Strain and Fermentation Studies
Overview
Pharmacology
Affiliations
Two strains of Actinoplanes have been isolated that produce a new peptide antibiotic named gardimycin. A detailed taxonomical study of such strains indicates that they differ between themselves and from all the described species of Actinoplanes. For this reason they are considered to be new species; for which the names A. garbadinensis nov. sp. and A. liguriae nov. sp. are proposed. The type strain of A. garbadinensis is A/10889(=ATCC 31049), the type strain of A. liguriae is A/6353 (=ATCC 31048). Studies on the medium and fermentation conditions are reported.
Mechanisms of action of ribosomally synthesized and posttranslationally modified peptides (RiPPs).
Cao L, Do T, Link A J Ind Microbiol Biotechnol. 2021; 48(3-4).
PMID: 33928382 PMC: 8183687. DOI: 10.1093/jimb/kuab005.
Construction of an expression system for site-directed mutagenesis of the lantibiotic mersacidin.
Szekat C, Jack R, Skutlarek D, Farber H, Bierbaum G Appl Environ Microbiol. 2003; 69(7):3777-83.
PMID: 12839744 PMC: 165212. DOI: 10.1128/AEM.69.7.3777-3783.2003.
Gardimycin, a new antibiotic inhibiting peptidoglycan synthesis.
Somma S, Merati W, Parenti F Antimicrob Agents Chemother. 1977; 11(3):396-401.
PMID: 404960 PMC: 351996. DOI: 10.1128/AAC.11.3.396.