Mu Opioid Receptor Knockout in Mice: Effects on Ligand-induced Analgesia and Morphine Lethality

Overview

Journal Brain Res Mol Brain Res

Specialties Molecular Biology
Neurology

Date 1998 May 16

PMID 9555078

Citations 90

Authors

H H Loh

H C Liu

A Cavalli

W Yang

Y F Chen

L N Wei

Affiliations

Soon will be listed here.

Abstract

The mu opioid receptor gene (MOR) was mutated in mice by a gene targeting procedure. In these MOR-knockout mice, the analgesic effects of morphine, its major metabolites, morphine-6-glucuronide (M-6-G) and morphine-6-ethereal sulfate (M-6-S), and endomorphin-2, as well as morphine-induced lethality, were drastically reduced, whereas the effects of DPDPE and U50488 remained unchanged. It is concluded that analgesic effects of mu-specific opioid ligands and acute morphine lethality are mediated by the mu receptor.

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