DNA-mediated Transformation in the Platyfish-swordtail Melanoma System

Overview

Journal Experientia

Specialty Science

Date 1976 Aug 15

PMID 955017

Citations 2

Authors

J Vielkind

F T Anders

Affiliations

Soon will be listed here.

Abstract

A genetic marker, the tumor gene Tu, which causes the formation of abnormal melanophores, the T-melanophores, in the skin of Xiphophorine fish has been transferred by donor DNA from a Tu genotype to recipient embryos lacking Tu. Abnormal melanophores which are identical to the T-melanophores of the donor genotype occurred only in recipients treated with Tu-DNA and not in those treated with Tu-free control DNA.

Citing Articles

Chromatophore development and cell interactions in the skin of xiphophorine fish.

Schmidt E Wilehm Roux Arch Dev Biol. 2017; 184(2):115-134.

PMID: 28305030 DOI: 10.1007/BF00848221.

The induction of a specific pigment cell type by total genomic DNA injected into the neural crest region of fish embryos of the genus Xiphophorus.

Vielkind J, Vielkind U, Anders F Mol Gen Genet. 1982; 185(3):379-89.

PMID: 6954345 DOI: 10.1007/BF00334128.

References

AVERY O, Macleod C, McCarty M . STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES : INDUCTION OF TRANSFORMATION BY A DESOXYRIBONUCLEIC ACID FRACTION ISOLATED FROM PNEUMOCOCCUS TYPE III. J Exp Med. 2009; 79(2):137-58. PMC: 2135445. DOI: 10.1084/jem.79.2.137. View

Hess D . [Transformations in higher organism]. Naturwissenschaften. 1972; 59(8):348-55. DOI: 10.1007/BF00617904. View

LEDOUX L . Uptake of DNA by living cells. Prog Nucleic Acid Res Mol Biol. 1965; 4:231-67. DOI: 10.1016/s0079-6603(08)60790-4. View

Schwab M, Vielkind J, Anders F . An approach to genetic transformation in the Xiphophorine fish. Mol Gen Genet. 1976; 144(2):151-8. DOI: 10.1007/BF02428103. View