High Throughput Analysis and Purification in Support of Automated Parallel Synthesis

Overview

Journal Mol Divers

Date 1997 Jan 1

PMID 9527477

Citations 2

Authors

H N Weller

M G Young

S J Michalczyk

G H Reitnauer

R S Cooley

P C Rahn

D J Loyd

D Fiore

S J Fischman

Affiliations

Soon will be listed here.

Abstract

Rapid reverse-phase analytical and preparative HPLC methods have been developed for application to parallel synthesis libraries. Gradient methods, short columns, and high flow rates allow analysis of over 300 compounds per day on a single system, or purification of up to 200 compounds per day on a single preparative system. Hardware and software modifications allow continuous unattended use for maximum efficiency and throughput.

Citing Articles

Fluorous mixture synthesis of two libraries with hydantoin-, and benzodiazepinedione-fused heterocyclic scaffolds.

Zhang W, Lu Y, Chen C, Zeng L, Kassel D J Comb Chem. 2006; 8(5):687-95.

PMID: 16961407 PMC: 1858674. DOI: 10.1021/cc060061e.

Purification of combinatorial libraries.

Weller H Mol Divers. 1999; 4(1):47-52.

PMID: 10320989 DOI: 10.1023/a:1009687711082.

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