Comparison of Post-stress Ejection Fraction and Relative Left Ventricular Volumes by Automatic Analysis of Gated Myocardial Perfusion Single-photon Emission Computed Tomography Acquired in the Supine and Prone Positions

Overview

Journal J Nucl Cardiol

Specialty Cardiology & Vascular Diseases

Date 1998 Mar 21

PMID 9504872

Citations 17

Authors

D Berman

G Germano

H Lewin

X Kang

P B Kavanagh

P Tapnio

M Harris

J Friedman

Affiliations

Soon will be listed here.

Abstract

Background: We have previously described an automatic method for measuring left ventricular ejection fraction (LVEF) for myocardial perfusion single-photon emission computed tomography (SPECT). The repeatability of this method has not been previously described.

Methods And Results: This study compares LVEF and relative end-systolic and end-diastolic volumes assessed from myocardial perfusion SPECT by our automatic method in 180 consecutive patients undergoing gated myocardial perfusion SPECT with injection of 99mTc-labeled sestamibi in whom the acquisitions were performed sequentially in supine and prone positions. The algorithm operated completely automatically in the prone and supine positions in 178 of the 180 patients. Very high correlations were observed for LVEF (r = 0.93), relative left ventricular end-systolic volume (r = 0.98), and relative left ventricular end-diastolic volume (r = 0.97). The mean paired absolute difference between LVEFs in the prone and supine position was 3.8+/-3.2, for left ventricular end-systolic volume was 4.9+/-4.8 ml, and for left ventricular end-diastolic volume was 7.4+/-6.7 ml. When patients were classified by the extent and severity of stress perfusion defect, there was no significant difference in repeatability for the measurements in any category.

Conclusions: Our algorithm for automatic quantification of LVEF and relative end-systolic and end-diastolic volumes from gated 99mTc sestamibi myocardial perfusion SPECT is repeatable. When performed in the prone position, values of ejection fractions and ventricular volumes are essentially identical to those obtained in the supine position.

Citing Articles

Prognostic value of summed motion score assessed by gated SPECT myocardial perfusion imaging in patients with dilated cardiomyopathy.

Zhu J, Wang X, Huang N, Li X, Cheng Y, Wu Z Front Cardiovasc Med. 2023; 10:1144333.

PMID: 37008320 PMC: 10050370. DOI: 10.3389/fcvm.2023.1144333.

New method for accurate estimations of LV function for small hearts.

Magota K, Tamaki N J Nucl Cardiol. 2016; 24(4):1393-1394.

PMID: 27251141 DOI: 10.1007/s12350-016-0548-6.

The Benefits of Prone SPECT Myocardial Perfusion Imaging in Reducing Both Artifact Defects and Patient Radiation Exposure.

Stathaki M, Koukouraki S, Papadaki E, Tsaroucha A, Karkavitsas N Arq Bras Cardiol. 2015; 105(4):345-52.

PMID: 26559981 PMC: 4632998. DOI: 10.5935/abc.20150122.

Cardiac function changes with switching from the supine to prone position: analysis by quantitative semiconductor gated single-photon emission computed tomography.

Shimizu M, Fujii H, Yamawake N, Nishizaki M J Nucl Cardiol. 2015; 22(2):301-7.

PMID: 25614336 DOI: 10.1007/s12350-014-0058-3.

Gated SPECT in assessment of regional and global left ventricular function: an update.

Abidov A, Germano G, Hachamovitch R, Slomka P, Berman D J Nucl Cardiol. 2013; 20(6):1118-43.

PMID: 24234974 DOI: 10.1007/s12350-013-9792-1.

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