The Use of Cyclosporin in Corticosteroid Dependent Asthma

Overview

Journal Arch Dis Child

Specialty Pediatrics

Date 1998 Mar 13

PMID 9496189

Citations 12

Authors

M E Coren

M Rosenthal

A Bush

Affiliations

Soon will be listed here.

Abstract

Five children with severe asthma requiring at least 10 mg of prednisolone daily were treated with cyclosporin. Three were weaned from prednisolone, but one quickly relapsed. One girl had her steroid dose lowered but suffered unacceptable hirsutism and one child failed to respond. Cyclosporin may be useful in refractory childhood asthma. A prospective study is required to confirm this.

Citing Articles

Identification of key genes and pathways between mild-moderate and severe asthmatics via bioinformatics analysis.

Wu X, Li R, Xu Q, Liu F, Jiang Y, Zhang M Sci Rep. 2022; 12(1):2549.

PMID: 35169275 PMC: 8847662. DOI: 10.1038/s41598-022-06675-w.

Assessment of the effectiveness of cyclosporine nasal spray in an animal model of allergic rhinitis.

Senturk E, Yildirim Y, Dogan R, Ozturan O, Guler E, Aydin M Eur Arch Otorhinolaryngol. 2017; 275(1):117-124.

PMID: 29071443 DOI: 10.1007/s00405-017-4786-2.

Extract and -Anethole Attenuate Ovalbumin-Induced Airway Inflammation via Enhancement of Foxp3 Regulatory T Cells and Inhibition of Th2 Cytokines in Mice.

Sung Y, Kim S, Kim D, Lee J, Kim H Mediators Inflamm. 2017; 2017:7506808.

PMID: 29062168 PMC: 5618762. DOI: 10.1155/2017/7506808.

Severe asthma in children.

Guilbert T, Bacharier L, Fitzpatrick A J Allergy Clin Immunol Pract. 2014; 2(5):489-500.

PMID: 25213041 PMC: 4589165. DOI: 10.1016/j.jaip.2014.06.022.

Therapeutic options for severe asthma.

Mathew J, Aronow W, Chandy D Arch Med Sci. 2012; 8(4):589-97.

PMID: 23056066 PMC: 3460493. DOI: 10.5114/aoms.2012.30280.

References

Corrigan C, Kay A . CD4 T-lymphocyte activation in acute severe asthma. Relationship to disease severity and atopic status. Am Rev Respir Dis. 1990; 141(4 Pt 1):970-7. DOI: 10.1164/ajrccm/141.4_Pt_1.. View

Azzawi M, Bradley B, Jeffery P, Frew A, Wardlaw A, Knowles G . Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am Rev Respir Dis. 1990; 142(6 Pt 1):1407-13. DOI: 10.1164/ajrccm/142.6_Pt_1.1407. View

Lock S, Kay A, Barnes N . Double-blind, placebo-controlled study of cyclosporin A as a corticosteroid-sparing agent in corticosteroid-dependent asthma. Am J Respir Crit Care Med. 1996; 153(2):509-14. DOI: 10.1164/ajrccm.153.2.8564089. View

Szefler S, Kamada A, Hughes D, Brenner A, Gelfand E . Alternative treatments for asthma: assessing the need. J Asthma. 1992; 29(2):91-7. DOI: 10.3109/02770909209059877. View

Moss R . Alternative pharmacotherapies for steroid-dependent asthma. Chest. 1995; 107(3):817-25. DOI: 10.1378/chest.107.3.817. View