Study of the Interaction of DNA with Cisplatin and Other Pd(II) and Pt(II) Complexes by Atomic Force Microscopy

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 1998 Apr 29

PMID 9490794

Citations 21

Authors

G B Onoa

G Cervantes

V Moreno

M J Prieto

Affiliations

Soon will be listed here.

Abstract

Modifications in the structure of a 260 bp DNA (hlyM) fragment from Escherichia coli caused by interaction with Pd(II) and Pt(II) complexes were studied. Cisplatin and transplatin [cis- and trans-PtCl2(NH3)2 respectively], Pt2Cl2(Spym)4 (Spym = 2-mercaptopyrimidine anion), Pd-famotidine and Pt-famotidine were incubated with DNA for 24 h at 37 degrees C and then observed with an atomic force microscope. Atomic force microscopy (AFM) provides the opportunity for nanometer resolution in research on the interaction between nucleic acids and metal complexes. The complexes induced noticeable changes in DNA topography according to their different characteristics and structure. In the case of cisplatin a shortening in DNA strands was observed. Transplatin and Pt2Cl2(Spym)4 caused shortening and compaction, whilst an aggregation of two strands was observed for the Pt-famotidine compound but not for the Pd-famotidine compound or the metal-free famotidine.

Citing Articles

Oleanolic acid inhibits aldo-keto reductase family 1 member B10-induced cancer stemness and avoids cisplatin-based chemotherapy resistance via the Snail signaling pathway in oral squamous cell carcinoma cell lines.

Ko H, Chou H, Hou H, Kuo W, Liu W, Yen-Ping Kuo M J Dent Sci. 2025; 20(1):100-108.

PMID: 39873100 PMC: 11762581. DOI: 10.1016/j.jds.2024.09.018.

Fibroblast growth factor signalling influences homologous recombination-mediated DNA damage repair to promote drug resistance in ovarian cancer.

Nicholson H, Sawers L, Clarke R, Hiom K, Ferguson M, Smith G Br J Cancer. 2022; 127(7):1340-1351.

PMID: 35778553 PMC: 9519926. DOI: 10.1038/s41416-022-01899-z.

Detection and Characterization of Single Cisplatin Adducts on DNA by Nanopore Sequencing.

Zhao X, Liu Y, Chen X, Mi Z, Li W, Wang P ACS Omega. 2021; 6(26):17027-17034.

PMID: 34250360 PMC: 8264939. DOI: 10.1021/acsomega.1c02106.

Why Concurrent CDDP and Radiotherapy Has Synergistic Antitumor Effects: A Review of In Vitro Experimental and Clinical-Based Studies.

Nagasawa S, Takahashi J, Suzuki G, Hideya Y, Yamada K Int J Mol Sci. 2021; 22(6).

PMID: 33808722 PMC: 8003508. DOI: 10.3390/ijms22063140.

Different Effects of Cisplatin and Transplatin on the Higher-Order Structure of DNA and Gene Expression.

Kishimoto T, Yoshikawa Y, Yoshikawa K, Komeda S Int J Mol Sci. 2019; 21(1).

PMID: 31861648 PMC: 6981875. DOI: 10.3390/ijms21010034.

References

Rosenberg B, VANCAMP L, Trosko J, Mansour V . Platinum compounds: a new class of potent antitumour agents. Nature. 1969; 222(5191):385-6. DOI: 10.1038/222385a0. View

Bustamante C, Rivetti C . Visualizing protein-nucleic acid interactions on a large scale with the scanning force microscope. Annu Rev Biophys Biomol Struct. 1996; 25:395-429. DOI: 10.1146/annurev.bb.25.060196.002143. View

Mong S, Daskal Y, Prestayko A, Crooke S . DNA supercoiling, shortening, and induction of single-strand regions by cis-diamminedichloroplatinum(II). Cancer Res. 1981; 41(10):4020-6. View

van der Veer J, den Hartog J, Lohman P, Reedijk J . Adducts of the antitumor drug cis-diamminedichloroplatinum(II) with DNA: formation, identification, and quantitation. Biochemistry. 1985; 24(3):707-13. DOI: 10.1021/bi00324a025. View

Sherman S, Gibson D, Wang A, Lippard S . X-ray structure of the major adduct of the anticancer drug cisplatin with DNA: cis-[Pt(NH3)2(d(pGpG))]. Science. 1985; 230(4724):412-7. DOI: 10.1126/science.4048939. View

Ciccarelli R, Solomon M, Varshavsky A, Lippard S . In vivo effects of cis- and trans-diamminedichloroplatinum(II) on SV40 chromosomes: differential repair, DNA-protein cross-linking, and inhibition of replication. Biochemistry. 1985; 24(26):7533-40. DOI: 10.1021/bi00347a005. View

Butour J, Johnson N . Chemical reactivity of monofunctional platinum-DNA adducts. Biochemistry. 1986; 25(16):4534-9. DOI: 10.1021/bi00364a012. View

Roberts J, Friedlos F . Differential toxicity of cis- and trans-diamminedichloroplatinum(II) toward mammalian cells: lack of influence of any difference in the rates of loss of their DNA-bound adducts. Cancer Res. 1987; 47(1):31-6. View

Van Oosterom A, Lohman P, Berends F . cis-Diamminedichloroplatinum(II)-induced DNA adducts in peripheral leukocytes from seven cancer patients: quantitative immunochemical detection of the adduct induction and removal after a single dose of cis-diamminedichloroplatinum(II). Cancer Res. 1987; 47(11):3000-4. View

10.

Eastman A, Barry M . Interaction of trans-diamminedichloroplatinum(II) with DNA: formation of monofunctional adducts and their reaction with glutathione. Biochemistry. 1987; 26(12):3303-7. DOI: 10.1021/bi00386a009. View

11.

Dijt F, Berends F, Reedijk J . Formation and repair of cisplatin-induced adducts to DNA in cultured normal and repair-deficient human fibroblasts. Cancer Res. 1988; 48(21):6058-62. View

12.

Atwell G, Baguley B, Denny W . Potential antitumor agents. 57. 2-Phenylquinoline-8-carboxamides as "minimal" DNA-intercalating antitumor agents with in vivo solid tumor activity. J Med Chem. 1989; 32(2):396-401. DOI: 10.1021/jm00122a018. View

13.

Wagstaff A, Ward A, Benfield P, Heel R . Carboplatin. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in the treatment of cancer. Drugs. 1989; 37(2):162-90. DOI: 10.2165/00003495-198937020-00005. View

14.

Perez J, Requena J, Jimenez-Ruiz A, Parrondo E, Craciunescu D, Lopez M . DNA binding properties and antileukemic (L1210) activity of a Pt-pentamidine complex. Chem Biol Interact. 1991; 77(3):341-55. DOI: 10.1016/0009-2797(91)90042-6. View

15.

Rampino N . Cisplatin induced alterations in oriented fibers of DNA studied by atomic force microscopy. Biochem Biophys Res Commun. 1992; 182(1):201-7. DOI: 10.1016/s0006-291x(05)80131-7. View

16.

Bustamante C, Vesenka J, Tang C, Rees W, Guthold M, Keller R . Circular DNA molecules imaged in air by scanning force microscopy. Biochemistry. 1992; 31(1):22-6. DOI: 10.1021/bi00116a005. View

17.

Hansma H, SINSHEIMER R, Li M, Hansma P . Atomic force microscopy of single- and double-stranded DNA. Nucleic Acids Res. 1992; 20(14):3585-90. PMC: 334005. DOI: 10.1093/nar/20.14.3585. View

18.

Vesenka J, Guthold M, Tang C, Keller D, Delaine E, Bustamante C . Substrate preparation for reliable imaging of DNA molecules with the scanning force microscope. Ultramicroscopy. 1992; 42-44 ( Pt B):1243-9. DOI: 10.1016/0304-3991(92)90430-r. View

19.

Hansma H, Bezanilla M, Zenhausern F, Adrian M, SINSHEIMER R . Atomic force microscopy of DNA in aqueous solutions. Nucleic Acids Res. 1993; 21(3):505-12. PMC: 309146. DOI: 10.1093/nar/21.3.505. View

20.

Coluccia M, Nassi A, Loseto F, Boccarelli A, Mariggio M, Giordano D . A trans-platinum complex showing higher antitumor activity than the cis congeners. J Med Chem. 1993; 36(4):510-2. DOI: 10.1021/jm00056a012. View