Characterization of the Bovine Epsilon Gene

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1998 Mar 5

PMID 9486110

Citations 3

Authors

M Mousavi

H Rabbani

L Hammarstrom

Affiliations

Soon will be listed here.

Abstract

Immunoglobulin E is quantitatively a minor immunoglobulin class in serum, but nevertheless the major class of antibody mediating type I hypersensitivity reactions and hence, type I allergic phenomena. The bovine epsilon gene is one of the as yet uncharacterized mammalian immunoglobulin genes. We have therefore cloned and determined the cDNA sequence and genomic organization of the gene. It contains four constant region domain-encoding exons (CH1 to CH4) with a high homology to sheep C epsilon (87%) and to a lower degree to dog (62%), horse (58%), chimpanzee, orangutan, human (55%), mouse (52%) and rat (52%) C epsilon genes. Southern blot analysis of bovine genomic DNA, revealed the existence of a single C epsilon gene with a presence of allelic restriction fragment length polymorphism (RFLP).

Citing Articles

The Unusual Genetics and Biochemistry of Bovine Immunoglobulins.

Stanfield R, Haakenson J, Deiss T, Criscitiello M, Wilson I, Smider V Adv Immunol. 2018; 137:135-164.

PMID: 29455846 PMC: 5935254. DOI: 10.1016/bs.ai.2017.12.004.

Passive immunity against human pathogens using bovine antibodies.

Weiner C, Pan Q, Hurtig M, Boren T, Bostwick E, Hammarstrom L Clin Exp Immunol. 1999; 116(2):193-205.

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Characterization of the gene for the membrane and secretory form of the IgM heavy-chain constant region gene (C mu) of the cow (Bos taurus).

Mousavi M, Rabbani H, Pilstrom L, Hammarstrom L Immunology. 1998; 93(4):581-8.

PMID: 9659232 PMC: 1364138. DOI: 10.1046/j.1365-2567.1998.00444.x.

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