[Osteoinduction and -reparation]

Overview

Journal Mund Kiefer Gesichtschir

Specialties Dentistry
General Surgery

Date 1997 Feb 1

PMID 9483923

Citations 6

Authors

N R Kubler

Affiliations

Soon will be listed here.

Abstract

Traumata, diseases, developmental deformities, and tumor resections frequently cause bone defects and atrophies. In general, three different mechanisms exist by which bone restoration can be achieved: (1) osteogenesis initiated by vital, osteoblastic cells of autografts; (2) osteoconduction (or creeping substitution); and (3) osteoinduction. The latter mechanism means the differentiation of pluripotent, mesenchymal-type cells (located in a recipient bed with strong regenerative capacity) into cartilage- and bone-forming progenitor cells under the influence of inductive bone morphogenetic proteins (BMPs). Some BMPs are physiologically included in low concentrations as organic components in bone tissue. They can diffuse from demineralized bone implants into the recipient bed and induce a differentiation into new bone tissue. Nine different BMPs have been isolated, characterized, and cloned. Some of these possess inductive properties and can initiate new bone formation in muscle tissue or in bone defects. In the future recombinant BMPs will be available in unlimited quantities. This will lead to completely new therapeutic concepts in reconstructive bone surgery.

Citing Articles

Horizontal Ridge Augmentation: A Comparison between Khoury and Urban Technique.

Sanchez-Sanchez J, Pickert F, Sanchez-Labrador L, Gf Tresguerres F, Martinez-Gonzalez J, Meniz-Garcia C Biology (Basel). 2021; 10(8).

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[Bone substitute. Transplants and replacement materials--an update].

Rentsch C, Rentsch B, Scharnweber D, Zwipp H, Rammelt S Unfallchirurg. 2012; 115(10):938-49.

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Release kinetics of VEGF165 from a collagen matrix and structural matrix changes in a circulation model.

Kleinheinz J, Jung S, Wermker K, Fischer C, Joos U Head Face Med. 2010; 6:17.

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Comparative in vitro study of the proliferation and growth of ovine osteoblast-like cells on various alloplastic biomaterials manufactured for augmentation and reconstruction of tissue or bone defects.

Schmitt S, Wiedmann-Al-Ahmad M, Kuschnierz J, Al-Ahmad A, Huebner U, Schmelzeisen R J Mater Sci Mater Med. 2007; 19(3):1441-50.

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[Applying an osteoinductive protein complex for regeneration of osseous defects].

Kloss F, Schlegel K, Felszeghy E, Falk S, Wiltfang J Mund Kiefer Gesichtschir. 2004; 8(1):12-7.

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References

PADGETT R, Wozney J, Gelbart W . Human BMP sequences can confer normal dorsal-ventral patterning in the Drosophila embryo. Proc Natl Acad Sci U S A. 1993; 90(7):2905-9. PMC: 46205. DOI: 10.1073/pnas.90.7.2905. View

Urist M, Dowell T . Inductive substratum for osteogenesis in pellets of particulate bone matrix. Clin Orthop Relat Res. 1968; 61:61-78. View

Esch F, Ueno N, Baird A, Hill F, Denoroy L, Ling N . Primary structure of bovine brain acidic fibroblast growth factor (FGF). Biochem Biophys Res Commun. 1985; 133(2):554-62. DOI: 10.1016/0006-291x(85)90942-8. View

. Senn on the Healing of Aseptic Bone Cavities by Implantation of Antiseptic Decalcified Bone. Ann Surg. 1889; 10(5):352-68. PMC: 1428311. DOI: 10.1097/00000658-188907000-00043. View

Urist M . Surface-decalcified allogeneic bone (SDAB) implants. A preliminary report of 10 cases and 25 comparable operations with undecalcified lyophilized bone implants. Clin Orthop Relat Res. 1968; 56:37-50. View

Nilsson O, Urist M . Immune inhibition of repair of canine skull trephine defects implanted with partially purified bovine morphogenetic protein. Int Orthop. 1991; 15(3):257-63. DOI: 10.1007/BF00192304. View

Yasko A, Lane J, Fellinger E, Rosen V, Wozney J, Wang E . The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2). A radiographic, histological, and biomechanical study in rats. J Bone Joint Surg Am. 1992; 74(5):659-70. View

Weiss R, Reddi A . Role of fibronectin in collagenous matrix-induced mesenchymal cell proliferation and differentiation in vivo. Exp Cell Res. 1981; 133(2):247-54. DOI: 10.1016/0014-4827(81)90316-5. View

Nogami H, Urist M . Transmembrane bone matrix gelatin-induced differentiation of bone. Calcif Tissue Res. 1975; 19(2):153-63. DOI: 10.1007/BF02563999. View

10.

Luyten F, Chen P, Paralkar V, Reddi A . Recombinant bone morphogenetic protein-4, transforming growth factor-beta 1, and activin A enhance the cartilage phenotype of articular chondrocytes in vitro. Exp Cell Res. 1994; 210(2):224-9. DOI: 10.1006/excr.1994.1033. View

11.

Kubler N, Reuther J, Kirchner T, Priessnitz B, Sebald W . Osteoinductive, morphologic, and biomechanical properties of autolyzed, antigen-extracted, allogeneic human bone. J Oral Maxillofac Surg. 1993; 51(12):1346-57. DOI: 10.1016/s0278-2391(10)80141-7. View

12.

Kato F . [Experimental study of chemical spinal fusion in the rabbit by means of bone morphogenetic protein]. Nihon Seikeigeka Gakkai Zasshi. 1990; 64(5):442-52. View

13.

Cunningham N, Paralkar V, Reddi A . Osteogenin and recombinant bone morphogenetic protein 2B are chemotactic for human monocytes and stimulate transforming growth factor beta 1 mRNA expression. Proc Natl Acad Sci U S A. 1992; 89(24):11740-4. PMC: 50632. DOI: 10.1073/pnas.89.24.11740. View

14.

Katagiri T, Yamaguchi A, Ikeda T, Yoshiki S, Wozney J, Rosen V . The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2. Biochem Biophys Res Commun. 1990; 172(1):295-9. DOI: 10.1016/s0006-291x(05)80208-6. View

15.

Prisell P, Edwall D, Lindblad J, Levinovitz A, Norstedt G . Expression of insulin-like growth factors during bone induction in rat. Calcif Tissue Int. 1993; 53(3):201-5. DOI: 10.1007/BF01321838. View

16.

Oklund S, PROLO D, Gutierrez R, King S . Quantitative comparisons of healing in cranial fresh autografts, frozen autografts and processed autografts, and allografts in canine skull defects. Clin Orthop Relat Res. 1986; (205):269-91. View

17.

Beck L, Amento E, Xu Y, DeGuzman L, Lee W, Nguyen T . TGF-beta 1 induces bone closure of skull defects: temporal dynamics of bone formation in defects exposed to rhTGF-beta 1. J Bone Miner Res. 1993; 8(6):753-61. DOI: 10.1002/jbmr.5650080614. View

18.

Urist M, Granstein R, Nogami H, Svenson L, Murphy R . Transmembrane bone morphogenesis across multiple-walled diffusion chambers. New evidence for a diffusible bone morphogenetic property. Arch Surg. 1977; 112(5):612-9. DOI: 10.1001/archsurg.1977.01370050072012. View

19.

Gerhart T, Kirker-Head C, Kriz M, Holtrop M, HENNIG G, Hipp J . Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein. Clin Orthop Relat Res. 1993; (293):317-26. View

20.

Thies R, Bauduy M, Ashton B, Kurtzberg L, Wozney J, Rosen V . Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells. Endocrinology. 1992; 130(3):1318-24. DOI: 10.1210/endo.130.3.1311236. View