The Endoplasmic Reticulum Ca2+ Store: a View from the Lumen

Overview

Journal Trends Biochem Sci

Specialty Biochemistry

Date 1998 Mar 28

PMID 9478128

Citations 142

Authors

J Meldolesi

T Pozzan

Affiliations

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Abstract

The endoplasmic reticulum (ER) and its specialized subcompartments such as the sarcoplasmic reticulum, is the main dynamic Ca2+ storage compartment of the cell. Key cellular functions are regulated, either directly or indirectly, by the free Ca2+ concentration in the ER. This article discusses the properties of Ca2+ storage in the ER and considers the functions that appear to be regulated by the Ca2+ stores within the ER, both in and around the ER and at a distance from it.

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