Suppression of Growth and Transformation and Induction of Apoptosis by EGR-1

Overview

Journal Cancer Gene Ther

Specialties Genetics
Oncology
Pharmacology

Date 1998 Feb 26

PMID 9476963

Citations 78

Authors

C Liu

V M Rangnekar

E Adamson

D Mercola

Affiliations

Soon will be listed here.

Abstract

Although cloned as an "immediate-early gene," recent studies show that EGR-1 functions in growth regulation and suppression of transformation by transactivation of the transforming growth factor beta-1 (TGF-beta1) gene and cooperation with Sp1, Jun-B, p21WAF1/Cip1, and stimulates apoptosis by transactivation of the p53 gene.

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