The Ubiquitin-proteasome Pathway in Cancer

Overview

Journal Br J Cancer

Specialty Oncology

Date 1998 Feb 24

PMID 9472642

Citations 51

Authors

V Spataro

C Norbury

A L Harris

Affiliations

Soon will be listed here.

Abstract

Degradation by the 26S proteasome of specific proteins that have been targeted by the ubiquitin pathway is the major intracellular non-lysosomal proteolytic mechanism and is involved in a broad range of processes, such as cell cycle progression, antigen presentation and control of gene expression. Recent work, reviewed here, has shown that this pathway is often the target of cancer-related deregulation and can underlie processes, such as oncogenic transformation, tumour progression, escape from immune surveillance and drug resistance.

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References

Peters J, Cejka Z, Harris J, Kleinschmidt J, Baumeister W . Structural features of the 26 S proteasome complex. J Mol Biol. 1993; 234(4):932-7. DOI: 10.1006/jmbi.1993.1646. View

Keyomarsi K, OLeary N, Molnar G, Lees E, Fingert H, Pardee A . Cyclin E, a potential prognostic marker for breast cancer. Cancer Res. 1994; 54(2):380-5. View

Polyak K, Kato J, Solomon M, Sherr C, Massague J, Roberts J . p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev. 1994; 8(1):9-22. DOI: 10.1101/gad.8.1.9. View

Chowdary D, Dermody J, Jha K, Ozer H . Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway. Mol Cell Biol. 1994; 14(3):1997-2003. PMC: 358559. DOI: 10.1128/mcb.14.3.1997-2003.1994. View

Ciechanover A, Shkedy D, Oren M, Bercovich B . Degradation of the tumor suppressor protein p53 by the ubiquitin-mediated proteolytic system requires a novel species of ubiquitin-carrier protein, E2. J Biol Chem. 1994; 269(13):9582-9. View

Fenteany G, Standaert R, REICHARD G, Corey E, Schreiber S . A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. Proc Natl Acad Sci U S A. 1994; 91(8):3358-62. PMC: 43576. DOI: 10.1073/pnas.91.8.3358. View

Mori S, Kanaki H, Tanaka K, Morisaki N, Saito Y . Ligand-activated platelet-derived growth factor beta-receptor is degraded through proteasome-dependent proteolytic pathway. Biochem Biophys Res Commun. 1995; 217(1):224-9. DOI: 10.1006/bbrc.1995.2767. View

Imajoh-Ohmi S, Kawaguchi T, Sugiyama S, Tanaka K, Omura S, Kikuchi H . Lactacystin, a specific inhibitor of the proteasome, induces apoptosis in human monoblast U937 cells. Biochem Biophys Res Commun. 1995; 217(3):1070-7. DOI: 10.1006/bbrc.1995.2878. View

Ferrando A, Balbin M, Pendas A, Vizoso F, Velasco G, Lopez-Otin C . Mutational analysis of the human cyclin-dependent kinase inhibitor p27kip1 in primary breast carcinomas. Hum Genet. 1996; 97(1):91-4. DOI: 10.1007/BF00218840. View

10.

Kumada K, Yanagida M, Toda T . Caffeine-resistance in fission yeast is caused by mutations in a single essential gene, crm1+. Mol Gen Genet. 1996; 250(1):59-68. DOI: 10.1007/BF02191825. View

11.

Philip P, Harris A . Potential for protein kinase C inhibitors in cancer therapy. Cancer Treat Res. 1995; 78:3-27. DOI: 10.1007/978-1-4615-2007-8_1. View

12.

Hengst L, Reed S . Translational control of p27Kip1 accumulation during the cell cycle. Science. 1996; 271(5257):1861-4. DOI: 10.1126/science.271.5257.1861. View

13.

Nandi D, Jiang H, Monaco J . Identification of MECL-1 (LMP-10) as the third IFN-gamma-inducible proteasome subunit. J Immunol. 1996; 156(7):2361-4. View

14.

Seliger B, Hohne A, Knuth A, Bernhard H, Meyer T, Tampe R . Analysis of the major histocompatibility complex class I antigen presentation machinery in normal and malignant renal cells: evidence for deficiencies associated with transformation and progression. Cancer Res. 1996; 56(8):1756-60. View

15.

Groettrup M, Soza A, Kloetzel P, Ehrlich R . LMP-associated proteolytic activities and TAP-dependent peptide transport for class 1 MHC molecules are suppressed in cell lines transformed by the highly oncogenic adenovirus 12. J Exp Med. 1996; 183(2):499-514. PMC: 2192445. DOI: 10.1084/jem.183.2.499. View

16.

Groettrup M, Kraft R, Kostka S, Standera S, Stohwasser R, Kloetzel P . A third interferon-gamma-induced subunit exchange in the 20S proteasome. Eur J Immunol. 1996; 26(4):863-9. DOI: 10.1002/eji.1830260421. View

17.

Chock P, Curran T, Yang D . Ubiquitinylation of transcription factors c-Jun and c-Fos using reconstituted ubiquitinylating enzymes. J Biol Chem. 1996; 271(9):4930-6. DOI: 10.1074/jbc.271.9.4930. View

18.

Gordon C, McGurk G, Wallace M, Hastie N . A conditional lethal mutant in the fission yeast 26 S protease subunit mts3+ is defective in metaphase to anaphase transition. J Biol Chem. 1996; 271(10):5704-11. DOI: 10.1074/jbc.271.10.5704. View

19.

Maki C, Huibregtse J, Howley P . In vivo ubiquitination and proteasome-mediated degradation of p53(1). Cancer Res. 1996; 56(11):2649-54. View

20.

Hisamatsu H, Shimbara N, Saito Y, Kristensen P, Hendil K, Fujiwara T . Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma. J Exp Med. 1996; 183(4):1807-16. PMC: 2192534. DOI: 10.1084/jem.183.4.1807. View