Up-regulation of Beta-actin, Cyclophilin and GAPDH in N1S1 Rat Hepatoma

Overview

Journal Oncol Rep

Specialty Oncology

Date 1998 Apr 18

PMID 9468581

Citations 24

Authors

T J Chang

C C Juan

P H Yin

C W Chi

H J Tsay

Affiliations

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Abstract

Beta-actin, cyclophilin and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) are all constantly expressed proteins that regulate cellular structures and endogenous cytoarchitectural functions. In this study, we used an in vivo N1S1 rat hepatoma model to examine changes in the expression levels of these housekeeping genes in normal and tumor liver samples. The beta-actin, cyclophilin and GAPDH genes were all up-regulated in tumor groups as compared to the controls. Our results suggest that up-regulation of beta-actin, cyclophilin and GAPDH genes may be essential for oncogenesis in hepatoma.

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