Relationship Between Rat Brain and Cisternal CSF Tryptophan Concentrations

Overview

Journal J Neurol Neurosurg Psychiatry

Publisher BMJ Publishing Group

Specialties Neurology
Neurosurgery
Psychiatry

Date 1976 Mar 1

PMID 945332

Citations 7

Authors

S N Young

P Etienne

T L Sourkes

Affiliations

Soon will be listed here.

Abstract

Tryptophan was measured in the cisternal CSF and brains of rats. In untreated rats there was a significant but not very close correlation between the tryptophan concentration in these two compartments. Factors that change the brain tryptophan concentration such as starvation, glucose feeding, and lithium treatment affected the CSF tryptophan in the same way as the brain tryptophan. Diurnal changes were parallel for brain and CSF. When we take into account our knowledge of the disposition of tryptophan in human CSF, these data suggest that measurement of lumbar CSF tryptophan in man may be a useful approach to the study of human brain tryptophan. However, because the correlation between brain and CSF is not very close, measurements on CSF tryptophan would be more meaningful in groups of patients than in individuals.

Citing Articles

Cerebrospinal fluid concentrations of tryptophan and 5-hydroxyindoleacetic acid in Macaca mulatta: diurnal variations and response to chronic changes in dietary protein intake.

Grimes M, Cameron J, Fernstrom J Neurochem Res. 2000; 25(3):413-22.

PMID: 10761988 DOI: 10.1023/a:1007557524370.

CNS tryptamine metabolism in hepatic coma.

Young S, Lal S J Neural Transm. 1980; 47(3):153-61.

PMID: 7381453 DOI: 10.1007/BF01250597.

Precursors and metabolites of phenylethylamine, m and p-tyramine and tryptamine in human lumbar and cisternal cerebrospinal fluid.

Young S, Davis B, Gauthier S J Neurol Neurosurg Psychiatry. 1982; 45(7):633-9.

PMID: 6181210 PMC: 491479. DOI: 10.1136/jnnp.45.7.633.

Effect of tryptophan administration on tryptophan, 5-hydroxyindoleacetic acid and indoleacetic acid in human lumbar and cisternal cerebrospinal fluid.

Young S, Gauthier S J Neurol Neurosurg Psychiatry. 1981; 44(4):323-8.

PMID: 6165809 PMC: 490955. DOI: 10.1136/jnnp.44.4.323.

Factors influencing monoamine metabolites and tryptophan in patients with alcohol dependence.

Banki C J Neural Transm. 1981; 50(2-4):89-101.

PMID: 6165805 DOI: 10.1007/BF01249132.

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