The Movement of TRNA Through the Ribosome

Overview

Journal Biophys J

Publisher Cell Press

Specialty Biophysics

Date 1998 Feb 4

PMID 9449359

Citations 2

Authors

J Frank

R K Agrawal

Affiliations

Soon will be listed here.

Abstract

The interaction between tRNA and the ribosome during translation, specifically during elongation, constitutes an example of the motion and adaptability of living molecules. Recent results obtained by cryoelectron microscopy of "naked" ribosomes and ribosomes in functional binding states shine some light on this fundamental life-sustaining process. Inspection of the surface contour of our reconstruction reveals a precise "lock-and-key" fit between the intersubunit space and the tRNA molecule.

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Visualization of tRNA movements on the Escherichia coli 70S ribosome during the elongation cycle.

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