Effects of Hypercalcemia on Water and Sodium Excretion by the Isolated Dog Kidney

Overview

Journal Pflugers Arch

Specialty Physiology

Date 1976 May 6

PMID 944913

Citations 4

Authors

J L Vanherweghem

J Ducobu

A Dhollander

C Toussaint

Affiliations

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Abstract

The effects of acute hypercalcemia on hemodynamics and on water and sodium excretion were studied on the blood-perfused isolated dog kidney. This model advantageously eliminates various factors which modify medullary osmolality and intrarenal hemodynamics, as well as collecting duct permeability. Calcium ion directly inhibits sodium reabsorption in the proximal tubule and in the ascending limb of Henle's loop, leading to increased sodium excretion rate and to decreased free water generation. The vasoconstrictive action of calcium, leading to decreased glomerular filtration rate, may mitigate the strong natriuretic effect of this ion.

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References

Nizet A, CUYPERS Y, Deetjen P, Kramer K . Functional capacity of the isolated perfused dog kidney. Pflugers Arch Gesamte Physiol Menschen Tiere. 1967; 296(3):179-95. DOI: 10.1007/BF00363758. View

Beck D, LEVITIN H, EPSTEIN F . Effect of intravenous infusions of calcium on renal concentrating ability. Am J Physiol. 1959; 197:1118-20. DOI: 10.1152/ajplegacy.1959.197.5.1118. View

BERLINER R, Bennett C . Concentration of urine in the mammalian kidney. Am J Med. 1967; 42(5):777-89. DOI: 10.1016/0002-9343(67)90095-2. View

Itskovitz H, STEMPER J, Pacholczyk D, McGiff J . Renal prostaglandins: determinants of intrarenal distribution of blood flow in the dog. Clin Sci Mol Med Suppl. 1973; 45 Suppl 1:321s-4. DOI: 10.1042/cs045321s. View

RECTOR Jr F, Brunner F, SELDIN D . Mechanism of glomerulotubular balance. I. Effect of aortic constriction and elevated ureteropelvic pressure on glomerular filtration rate, fractional reabsorption, transit time, and tubular size in the proximal tubule of the rat. J Clin Invest. 1966; 45(4):590-602. PMC: 292733. DOI: 10.1172/JCI105373. View

Curran P, Herrera F, FLANIGAN W . The effect of Ca and antidiuretic hormone on Na transport across frog skin. II. Sites and mechanisms of action. J Gen Physiol. 1963; 46:1011-27. PMC: 2195298. DOI: 10.1085/jgp.46.5.1011. View

CHEN Jr P, NEUMAN W . Renal excretion of calcium by the dog. Am J Physiol. 1955; 180(3):623-31. DOI: 10.1152/ajplegacy.1955.180.3.623. View

Dibona G . Effect of hypercalcemia on renal tubular sodium handling in the rat. Am J Physiol. 1971; 220(1):49-53. DOI: 10.1152/ajplegacy.1971.220.1.49. View

Rosenbaum B, Kinney M, Scudder F, DiScala V, STEIN R . Effects of potassium depletion on renal tubular sodium and water reabsorption in the dog. Am J Physiol. 1972; 222(4):928-37. DOI: 10.1152/ajplegacy.1972.222.4.928. View

10.

Guignard J, BARRACLOUGH M, Jones N . [Effect of an intravenous infusion of calcium on the mechanism of urinary concentration]. Helv Physiol Pharmacol Acta. 1968; 26(3):CR348-50. View

11.

Frohlich E, Scott J, Haddy F . Effect of cations on resistance and responsiveness of renal and forelimb vascular beds. Am J Physiol. 1962; 203:583-7. DOI: 10.1152/ajplegacy.1962.203.3.583. View

12.

Vanherweghem J, Ducobu J, Dhollander A . Effects of indomethacin on renal hemodynamics and on water and sodium excretion by the isolated dog kidney. Pflugers Arch. 1975; 357(3-4):243-52. DOI: 10.1007/BF00585979. View

13.

Edwards B, Sutton R, Dirks J . Effect of calcium infusion on renal tubular reabsorption in the dog. Am J Physiol. 1974; 227(1):13-8. DOI: 10.1152/ajplegacy.1974.227.1.13. View

14.

EPSTEIN F . Calcium and the kidney. Am J Med. 1968; 45(5):700-14. DOI: 10.1016/0002-9343(68)90206-4. View

15.

Vanherwighem J, Ducobu J, Dhollander A, Toussaint C . Interactions between furosemide and vasopressin on hemodynamics and on water excretion by the isolated dog kidney. Pflugers Arch. 1976; 362(3):265-70. DOI: 10.1007/BF00581180. View

16.

Davis J, Schnermann J . The effect of antidiuretic hormone on the distribution of nephron filtration rates in rats with hereditary diabetes insipidus. Pflugers Arch. 1971; 330(4):323-34. DOI: 10.1007/BF00588584. View

17.

Suki W, Eknoyan G, RECTOR Jr F, SELDIN D . The renal diluting and concentrating mechanism in hypercalcemia. Nephron. 1969; 6(1):50-61. DOI: 10.1159/000179715. View

18.

Massry S, Coburn J, Chapman L, Kleeman C . Role of serum Ca, parathyroid hormone, and NaCl infusion on renal Ca and Na clearances. Am J Physiol. 1968; 214(6):1403-9. DOI: 10.1152/ajplegacy.1968.214.6.1403. View

19.

Bennett C . Urine concentration and dilution in hypokalemic and hypercalcemic dogs. J Clin Invest. 1970; 49(7):1447-57. PMC: 322618. DOI: 10.1172/JCI106362. View

20.

Berkowitz H, Miller L, Itskovitz H, Bovee K . Renal function in the iso- lated perfused kidney. Surg Gynecol Obstet. 1968; 127(6):1257-66. View