The Influence of Glucagon on Hepatic Glycogen Mobilization in Exercising Rats

Overview

Journal Pflugers Arch

Specialty Physiology

Date 1976 May 6

PMID 944910

Citations 4

Authors

H Galbo

J J Holst

Affiliations

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Abstract

The significance of glucagon for the alterations in carbohydrate and fat metabolism during swimming has been evaluated. Fed, male rats were used. Blood was drawn by cardiac puncture for glucose analysis and either rabbit-antiglucagonserum (A-rats) or normal rabbitserum (N-rats) injected. Twenty-nine rats were then forced to swim (S-rats) with a tail weight for 60 min, while 16 rats were resting controls (C-rats). Subsequently blood was drawn and samples of liver and muscle tissue collected. In SN-rats glucagon concentrations increased from 152 +/- 18 (S.E.) pg/ml (CN-rats) to 332 +/- 61 (P less than 0.05), while liver glycogen decreased (P less than 0.001) and blood glucose increased (P less than 0.05). In SA-rats, however, the changes in liver glycogen and blood glucose were halved indicating that increased glucagon secretion enhances hepatic glycogen depletion during prolonged exercise. NEFA rose in SA-rats (P less than 0.005) as well as in SN-rats (P less than 0.05). Glycerol concentrations, however, only increased in SA-rats (P less than 0.05) indicating a shift towards lipid combustion in antibody treated rats. Muscle glycogen and plasma insulin diminished and blood lactate increased uniformly in exercised rats.

Citing Articles

Comparison of the effects of intravenous and intrasplenic infusions of glucagon on cardiac output and its distribution in the rat.

Nichols A, Hiley C Naunyn Schmiedebergs Arch Pharmacol. 1987; 335(3):344-50.

PMID: 3587376 DOI: 10.1007/BF00172809.

The effect of intraportal and peripheral infusions of glucagon on insulin and glucose concentrations and glucose tolerance in normal man.

Holst J, Madsen O, Knop J, Schmidt A Diabetologia. 1977; 13(5):487-90.

PMID: 908472 DOI: 10.1007/BF01234501.

Neutralization of glucagon by antiserum as a tool in glucagon physiology. Lack of depression of basal blood glucose after antiserum treatment in rats.

Holst J, Galbo H, Richter E J Clin Invest. 1978; 62(1):182-90.

PMID: 659632 PMC: 371752. DOI: 10.1172/JCI109104.

Lak of influence of glucagon on glucose homeostasis after prolonged exercise in rats.

Galbo H, Richter E, Holst J, Christensen N Pflugers Arch. 1977; 369(1):21-5.

PMID: 560004 DOI: 10.1007/BF00580805.

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