Prostaglandins: Critical Roles in Pregnancy and Colon Cancer

Overview

Journal Curr Biol

Publisher Cell Press

Specialty Biology

Date 1998 Apr 16

PMID 9443907

Citations 6

Authors

P W MAJERUS

Affiliations

Soon will be listed here.

Abstract

Cyclooxygenase catalyses a key step in prostaglandin biosynthesis, and recent work suggests that one isoenzyme, COX-2, has important roles in early stages of pregnancy; it also appears to be involved in the somewhat analogous process of colon tumor formation and spread.

Citing Articles

Changes in erythrocyte membrane epoxyeicosatrienoic, dihydroxyeicosatrienoic, and hydroxyeicosatetraenoic acids during pregnancy.

Somani S, Zeigler M, Fay E, Leahy M, Bermudez B, Totah R Life Sci. 2020; 264:118590.

PMID: 33069736 PMC: 7755749. DOI: 10.1016/j.lfs.2020.118590.

Understanding the Interplay between COX-2 and hTERT in Colorectal Cancer Using a Multi-Omics Analysis.

Ayiomamitis G, Notas G, Vasilakaki T, Tsavari A, Vederaki S, Theodosopoulos T Cancers (Basel). 2019; 11(10).

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Colorectal Cancer in Pregnancy: Driven by Pregnancy-Associated Growth Factors?.

Ho M, Cassano-Bailey A, Czaykowski P J Gastrointest Cancer. 2012; 43 Suppl 1:S239-42.

PMID: 22581417 DOI: 10.1007/s12029-012-9394-1.

Germinated brown rice (GBR) reduces the incidence of aberrant crypt foci with the involvement of beta-catenin and COX-2 in azoxymethane-induced colon cancer in rats.

Latifah S, Armania N, Tze T, Azhar Y, Nordiana A, Norazalina S Nutr J. 2010; 9:16.

PMID: 20346115 PMC: 2868780. DOI: 10.1186/1475-2891-9-16.

Inhibition of the MEK1/ERK pathway reduces arachidonic acid release independently of cPLA2 phosphorylation and translocation.

Evans J, Fergus D, Leslie C BMC Biochem. 2002; 3:30.

PMID: 12370087 PMC: 130032. DOI: 10.1186/1471-2091-3-30.