The Road Less Travelled: C-kit and Stem Cell Factor

Overview

Journal J Neurooncol

Publisher Springer

Date 1998 Jan 24

PMID 9440029

Citations 4

Authors

W Hamel

M Westphal

Affiliations

Soon will be listed here.

Abstract

Autocrine stimulation of growth factor receptors by autonomously produced ligands regulates different aspects of cellular transformation and progression. In several tumors, including gliomas, multiple autocrine systems are activated and may exert different functions in the malignant transformation process. The c-kit proto-oncogene is widely expressed in human gliomas, and it may be activated by its co-expressed ligand, stem cell factor (SCF). Studies in glioma cell lines as well as different tumor types suggest the possibility of intracellular interactions of c-kit with SCF. Although c-kit and SCF may not play a primary and causal role in the initiation and progression of glial tumors they may still be contributing factors in glioma biology. It can be hypothesized that the parallel activation of several autocrine systems including some of which have found less attention in gliomas, such as c-kit/SCF, could compromise the efficacy of therapies targeting different autocrine loops. A better understanding of the multiplicity and mechanisms of autocrine stimulation has implications for the development of new therapies interfering with autocrine tumor cell growth.

Citing Articles

Targeted gene delivery to CD117-expressing cells in vivo with lentiviral vectors co-displaying stem cell factor and a fusogenic molecule.

Froelich S, Ziegler L, Stroup K, Wang P Biotechnol Bioeng. 2009; 104(1):206-15.

PMID: 19452500 PMC: 2716405. DOI: 10.1002/bit.22378.

Lack of CD117 and rare bcl-2 expression in stomach cancer by immunohistochemistry. An immunohistochemical study with review of the literature.

Mireskandari M, Shafaii A, Kayser G, Kayser K Diagn Pathol. 2006; 1:7.

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Selective migration of neuralized embryonic stem cells to stem cell factor and media conditioned by glioma cell lines.

Serfozo P, Schlarman M, Pierret C, Maria B, Kirk M Cancer Cell Int. 2006; 6:1.

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CD117 expression in glial tumors.

Cetin N, Dienel G, Gokden M J Neurooncol. 2005; 75(2):195-202.

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