Article: Inhibition of the development of myringosclerosis by local administration of fenspiride, an anti-inflammatory drug

Earlier studies have revealed a relationship between the development of myringosclerosis and oxygen-derived free radicals. The latter can be blocked by the anti-inflammatory drug fenspiride. The present study was undertaken to test the ability of fenspiride to prevent myringosclerosis from developing during healing of the tympanic membrane. Myringotomized rats were treated with either topical applications or intraperitoneal injections of fenspiride for 12 days, after which the tympanic membranes were examined by otomicroscopy and studied histologically by light microscopy. Topically applied fenspiride was found to inhibit the development of sclerotic lesions, whereas intraperitoneal injections were ineffective.

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References

1.

Fraysse B, CALVET H, Faure P, Schutz D . Value of fenspiride (Pneumorel 80 mg) in the preoperative treatment of chronic open tympanum otitis. Double-blind placebo-controlled study. Rhinol Suppl. 1988; 4:31-41. View

2.

Sallebert L, Schutz D . Value of Pneumorel 80 mg in the treatment of chronic otitis in adults. Multicentre study of 696 cases. Rhinol Suppl. 1988; 4:43-58. View

3.

Lonchampt M, Evrard Y, DUHAULT J . Recent data on the pharmacology of fenspiride. Rhinol Suppl. 1988; 4:59-66. View

4.

Albiin N, Hellstrom S, SALEN B, Stenfors L, Wirell S . The vascular supply of the rat tympanic membrane. Anat Rec. 1985; 212(1):17-22. DOI: 10.1002/ar.1092120103. View

5.

Hellstrom S, Spandow O . Exogenous heparin, topically administered, aids the remodelling of connective tissue in the healing of experimental tympanic membrane perforations. ORL J Otorhinolaryngol Relat Spec. 1994; 56(1):45-50. DOI: 10.1159/000276607. View

6.

Mattsson C, Marklund S, Hellstrom S . Application of oxygen free radical scavengers to diminish the occurrence of myringosclerosis. Ann Otol Rhinol Laryngol. 1997; 106(6):513-8. DOI: 10.1177/000348949710600613. View

7.

Cuenant G . Efficacy of Pneumorel 80 mg (fenspiride) in the treatment of chronic sinusitis. Double-blind placebo-controlled study. Rhinol Suppl. 1988; 4:21-9. View

8.

Cunha F, Boukili M, da Motta J, Vargaftig B, Ferreira S . Blockade by fenspiride of endotoxin-induced neutrophil migration in the rat. Eur J Pharmacol. 1993; 238(1):47-52. DOI: 10.1016/0014-2999(93)90503-a. View

9.

Laurent C, Hellstrom S, Fellenius E . Hyaluronan improves the healing of experimental tympanic membrane perforations. A comparison of preparations with different rheologic properties. Arch Otolaryngol Head Neck Surg. 1988; 114(12):1435-41. DOI: 10.1001/archotol.1988.01860240085029. View

10.

Kukreja R, KONTOS H, Hess M, ELLIS E . PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH. Circ Res. 1986; 59(6):612-9. DOI: 10.1161/01.res.59.6.612. View

11.

Mattsson C, Magnuson K, Hellstrom S . Myringosclerosis caused by increased oxygen concentration in traumatized tympanic membranes. Experimental study. Ann Otol Rhinol Laryngol. 1995; 104(8):625-32. DOI: 10.1177/000348949510400807. View

Inhibition of the Development of Myringosclerosis by Local Administration of Fenspiride, an Anti-inflammatory Drug