GEFs, GAPs, GDIs and Effectors: Taking a Closer (3D) Look at the Regulation of Ras-related GTP-binding Proteins

Overview

Journal Curr Opin Struct Biol

Date 1998 Jan 22

PMID 9434896

Citations 45

Authors

M Geyer

A Wittinghofer

Affiliations

Soon will be listed here.

Abstract

Cell biology depends on the interactions of macromolecules, such as protein-DNA, protein-protein or protein-nucleotide interactions. GTP-binding proteins are no exception to the rule. They regulate cellular processes as diverse as protein biosynthesis and intracellular membrane trafficking. Recently, a large number of genes encoding GTP-binding proteins and the proteins that interact with these molecular switches have been cloned and expressed. The 3D structures of some of these have also been elucidated.

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