Wallerian Degeneration in ICAM-1-deficient Mice

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 1998 Jan 9

PMID 9422541

Citations 4

Authors

V I Vougioukas

S Roeske

U Michel

W Bruck

Affiliations

Soon will be listed here.

Abstract

Wallerian degeneration of the peripheral nervous system was studied in ICAM-1-deficient mice and compared with the phenomena observed in C57BL wild-type animals. There was a decrease in myelin density in both mice strains 4 and 6 days after transection of the sciatic nerve. The degenerating nerves were invaded by Mac-1-, LFA-1-, and F4/80-positive macrophages; significantly lower numbers of macrophages were present in ICAM-1-deficient nerves. Myelin loss decreased after nerve transection with a more prominent loss in ICAM-1-deficient animals. Schwann cells revealed a much higher myelin load in these animals when compared with wild-type nerves, and there was an increased proliferation of endoneurial cells in ICAM-1-deficient mice. These data indicate that ICAM-1 is involved in macrophage recruitment to injured peripheral nerves as well as in the proliferative and phagocytic response of Schwann cells after peripheral nerve transection.

Citing Articles

Review: Myelin clearance is critical for regeneration after peripheral nerve injury.

Yuan Y, Wang Y, Wu S, Zhao M Front Neurol. 2023; 13:908148.

PMID: 36588879 PMC: 9801717. DOI: 10.3389/fneur.2022.908148.

Neutrophils Are Critical for Myelin Removal in a Peripheral Nerve Injury Model of Wallerian Degeneration.

Lindborg J, Mack M, Zigmond R J Neurosci. 2017; 37(43):10258-10277.

PMID: 28912156 PMC: 5656991. DOI: 10.1523/JNEUROSCI.2085-17.2017.

Macrophages are eliminated from the injured peripheral nerve via local apoptosis and circulation to regional lymph nodes and the spleen.

Kuhlmann T, Bitsch A, Stadelmann C, Siebert H, Bruck W J Neurosci. 2001; 21(10):3401-8.

PMID: 11331370 PMC: 6762479.

Nerve injury, axonal degeneration and neural regeneration: basic insights.

Stoll G, Muller H Brain Pathol. 1999; 9(2):313-25.

PMID: 10219748 PMC: 8098499. DOI: 10.1111/j.1750-3639.1999.tb00229.x.

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